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首页> 外文期刊>RSC Advances >Biocompatible surface modification of nano-scale zeolitic imidazolate frameworks for enhanced drug delivery
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Biocompatible surface modification of nano-scale zeolitic imidazolate frameworks for enhanced drug delivery

机译：纳米级咪唑沸石骨架的生物相容性表面修饰，可增强药物递送

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Recently, nanoscale metal organic frameworks have attracted considerable attention as a novel drug delivery system platform owing to their highly efficient drug loading and delivery capacities. However, their low dispersity in aqueous media, poor biocompatibility, and non-active targeting ability seriously limit their further clinical application. To address these issues, a hyaluronic acid (HA)-coated ZIF-8 nanocomposite (CCM@ZIF-8/HA) was successfully developed for use in anti-cancer treatment through efficient curcumin (CCM) delivery. The resultant CCM@ZIF-8/HA showed a long-term pH-dependent controlled drug release based on the core–shell structure of the encapsulation by HA. Moreover, compared to bare CCM@ZIF-8, the obtained ternary assembly showed enhanced dispersity in PBS, promoted cellular uptake, and greater growth inhibition against HeLa cells. Thus, CCM@ZIF-8/HA can not only serve as an ideal drug carrier, but it can also provide a general surface modification strategy to promote the performance of metal organic frameworks for efficient drug delivery.
机译：近来，由于其高效的药物装载和递送能力，作为新型药物递送系统平台的纳米级金属有机骨架已经引起了相当大的关注。然而，它们在水性介质中的低分散性，较差的生物相容性和非活性靶向能力严重限制了它们的进一步临床应用。为了解决这些问题，成功开发了透明质酸（HA）涂层的ZIF-8纳米复合材料（CCM @ ZIF-8 / HA），可通过有效的姜黄素（CCM）递送用于抗癌治疗。由此产生的CCM @ ZIF-8 / HA根据HA包封的核壳结构，显示了长期的pH依赖性药物控制释放。而且，与裸露的CCM @ ZIF-8相比，所获得的三元组装体在PBS中的分散性增强，促进了细胞摄取，并且对HeLa细胞的生长抑制更大。因此，CCM @ ZIF-8 / HA不仅可以用作理想的药物载体，而且还可以提供一般的表面改性策略，以促进金属有机骨架的性能，从而实现高效的药物输送。

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