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首页> 外文期刊>RSC Advances >Angelica gigas ameliorates the destruction of gingival tissues via inhibition of MMP-9 activity
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Angelica gigas ameliorates the destruction of gingival tissues via inhibition of MMP-9 activity

机译：当归可通过抑制MMP-9活性改善牙龈组织的破坏

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Angelica gigas (AG) has been used for periodontal diseases in traditional Korean medicine. However, the effects of AG on periodontitis have not been clarified yet. In this study, we investigated the ameliorative effects of AG against ligature-induced periodontitis. Sprague-Dawley rats were divided into four groups; non-ligatured (normal), ligatured and treated with vehicle (ligatured), ligatured and treated with 1 mg mL ~(?1) AG (AG1), and ligatured and treated with 100 mg mL ~(?1) AG (AG100). 70% ethanol extracts of AG were topically applied onto both sides of the first molar daily for 14 days. In addition, human dermal fibroblast cells were treated with 1, 10 and 100 μg mL ~(?1) AG to characterize the expression of matrix metallopeptidase 9 (MMP-9). Topical AG treatment reduced alveolar bone resorption, as assessed by methylene blue staining. The structures of soft gingival tissues (periodontal pocket) were recovered in the AG-treated groups. The expression of MMP-9 was decreased, and that of type 1 collagen was significantly increased in AG-treated gingival tissues. In addition, AG treatment inhibited the activity of MMP-9 in LPS-treated human dermal fibroblast cells. This study reveals that topical AG treatment has the potential to ameliorate the destruction of gingival tissues by inhibiting MMP-9 activity. AG may be a candidate for the treatment of periodontitis.
机译：当归（AG）已被用于韩国传统医学的牙周疾病。但是，AG对牙周炎的作用尚未阐明。在这项研究中，我们调查了AG对结扎诱导的牙周炎的改善作用。 Sprague-Dawley大鼠分为四组。未连接（正常），已连接并用溶媒处理（已连接），已连接并用1 mg mL〜（？1）AG（AG1）处理并已连接并已用100 mg mL〜（？1）AG（AG100）处理。每天将70％的AG乙醇提取物局部涂抹在第一磨牙的两侧，持续14天。另外，用1、10和100μgmL〜（Δ1）AG处理人皮肤成纤维细胞，以表征基质金属肽酶9（MMP-9）的表达。通过亚甲蓝染色评估，局部AG治疗可减少牙槽骨吸收。在AG治疗组中恢复了软牙龈组织的结构（牙周袋）。 AG处理的牙龈组织中MMP-9的表达降低，而1型胶原的表达显着增加。另外，AG处理抑制了LPS处理的人皮肤成纤维细胞中MMP-9的活性。这项研究表明，局部AG治疗具有通过抑制MMP-9活性来改善牙龈组织破坏的潜力。 AG可能是治疗牙周炎的候选药物。

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