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Factors affecting the structure of lyotropic liquid crystals and the correlation between structure and drug diffusion

机译：溶致液晶结构的影响因素及结构与药物扩散的关系

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摘要

Lyotropic liquid crystals (LLCs) formed by the self-assembly of amphiphilic molecules in a solvent (usually water) have attracted increasingly greater attention in the last few decades, especially the lamellar phase (L _(α) ), the reversed bicontinuous cubic phase (Q _(2) ) and the reversed hexagonal phase (H _(2) ). Such phases offer promising prospects for encapsulation of a wide range of target molecules with various sizes and polarities owing to the unique internal structures. Also, different structures of mesophases can give rise to different diffusion coefficients. The bicontinuous cubic phase and the hexagonal phase have been demonstrated to control and sustain the release of active molecules. Furthermore, the structures are susceptible to many factors such as water content, temperature, pH, the presence of additives etc. Many researchers have been studying these influencing factors in order to accurately fabricate the desired phase. In this paper, we give a review of the characteristics of different structures of liquid crystalline phases, the influencing factors on the phase transition of liquid crystals and the relationship between structures of LLC and drug diffusion. We hope our review will provide some insights into how to manipulate in a controlled manner the rate of incorporating and transferring molecules by altering the structure of lyotropic mesophases.
机译：在过去的几十年中，由两亲性分子在溶剂（通常是水）中自组装形成的溶致液晶（LLC）引起了越来越多的关注，特别是层状相（L _（α）），即反向双连续立方相（Q _（2））和反相六边形相（H _（2））。由于独特的内部结构，此类相为包封具有各种大小和极性的多种靶分子提供了有希望的前景。同样，中间相的不同结构可以引起不同的扩散系数。已证明双连续立方相和六方相可控制和维持活性分子的释放。此外，该结构易受许多因素的影响，例如水含量，温度，pH，添加剂的存在等。许多研究人员已经研究了这些影响因素，以精确地制造所需的相。本文综述了液晶相不同结构的特征，影响液晶相变的因素以及LLC结构与药物扩散之间的关系。我们希望我们的评论将提供一些见解，以了解如何通过改变溶致中间相的结构，以可控的方式控制掺入和转移分子的速率。

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