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首页> 外文期刊>RSC Advances >Photostability and antioxidant activity studies on the inclusion complexes of trans-polydatin with β-cyclodextrin and derivatives
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Photostability and antioxidant activity studies on the inclusion complexes of trans-polydatin with β-cyclodextrin and derivatives

机译：反式聚腺苷与β-环糊精及其衍生物包合物的光稳定性和抗氧化活性研究

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摘要

The inclusion complexes of trans -polydatin and three cyclodextrins (CDs), namely β-cyclodextrin (β-CD), methyl-β-cyclodextrin (Me-β-CD) and (2-hydroxy) propyl-β-cyclodextrin (HP-β-CD) were prepared. The effects of the inclusion behavior of trans -polydatin with three kinds of CDs were investigated in both solution and the solid state with the following methods: phase-solubility, X-ray diffraction (XRD), thermogravimetric analysis (TG), differential scanning calorimetry (DSC), and scanning electron microscopy (SEM), proton nuclear magnetic resonance ( ~(1) H-NMR) and two-dimensional rotational frame nuclear overhauser effect spectroscopy (2D ROESY). The results indicated that trans -polydatin formed a 1?:?1 stoichiometric inclusion complex with CDs. Meanwhile, the solubility and thermal stability of the inclusion complexes were improved after encapsulating by CDs. Furthermore, the photostability of trans -polydatin was enhanced after forming the inclusion complexes. The antioxidant activities results showed that the antioxidant performance of the inclusion complexes was enhanced in comparison to the native trans -polydatin. Therefore, it can be a potentially promising way to promote its drug bioavailability or phytochemical preparations.
机译：反式聚腺苷与三种环糊精（CD）的包合物，即β-环糊精（β-CD），甲基-β-环糊精（Me-β-CD）和（2-羟基）丙基-β-环糊精（HP-制备了β-CD。通过以下方法研究了溶液中和固态下反式聚拉丁肽与三种CD的包合行为：相溶性，X射线衍射（XRD），热重分析（TG），差示扫描量热法（DSC），扫描电子显微镜（SEM），质子核磁共振（〜（1）H-NMR）和二维旋转框架核Overhauser效应光谱（2D ROESY）。结果表明，反式聚腺苷与CD形成1∶1∶1化学计量的包合物。同时，CD包封后，包合物的溶解度和热稳定性得到改善。此外，形成包合物后，反式聚腺苷的光稳定性增强。抗氧化剂活性的结果表明，与天然反式聚丁二烯相比，包合物的抗氧化剂性能得到了提高。因此，这可能是促进其药物生物利用度或植物化学制剂的潜在有前途的方法。

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