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Anti-inflammatory potency of Locusta migratoria manilensis cyclopeptides in mast cells and macrophages

机译：东方蝗基因环肽对肥大细胞和巨噬细胞的抗炎作用

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Locusts are esteemed as a traditional Chinese medicine, as well as tonic foods in Asian countries. While searching for natural anti-inflammatory agents in natural products, we isolated four novel locust cyclopeptides (LCPs) and the results show that [cyclo-(Trp-Leu-His-Thr)]～LCP-3 has potent anti-inflammatory potency in RAW264.7 and HMC-1 cells under LPS (lipopolysaccharide) stimuli. Furthermore, mechanistic studies show that LCP-3 attenuates pro-inflammatory cytokine (TNF-α, IL-6, IL-1β, NO and PGE2) expression. Moreover, LCP-3 attenuates inflammatory damage associated with the direct inhibition of iNOS and COX-2 expression. LCP-3 also regulates the MAPK, PI3K/AKT and NF-κB pathways to attenuate LPS-induced damage. Of note, our study first reports the anti-inflammatory potency of LCPs and elucidates their underlying molecular mechanisms.
机译：蝗虫被视为传统中药，在亚洲国家也被视为补品食品。在天然产物中寻找天然抗炎药时，我们分离了四种新型蝗虫环肽（LCPs），结果表明[cyclo-（Trp-Leu-His-Thr）]〜LCP-3具有有效的抗炎作用。 LPS（脂多糖）刺激下的RAW264.7和HMC-1细胞。此外，机理研究表明，LCP-3减弱了促炎细胞因子（TNF-α，IL-6，IL-1β，NO和PGE2）的表达。而且，LCP-3减轻了与直接抑制iNOS和COX-2表达有关的炎症损伤。 LCP-3还调节MAPK，PI3K / AKT和NF-κB通路，以减轻LPS诱导的损伤。值得注意的是，我们的研究首先报道了LCP的抗炎作用，并阐明了其潜在的分子机制。

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