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Graphene quantum dots mediated electron transfer in DNA base pairs

机译：石墨烯量子点介导的DNA碱基对中的电子转移

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Graphene quantum dots (GQDs) were connected to [Ru(bpy) _(3) ] ~(2+) to sense DNA-mediated charge transfer. Interaction between abasic site double stranded DNA (Abasic-DNA) and [Ru(bpy) _(3) –GQD] ~(2+) was investigated by absorption spectroscopy, gel electrophoresis, circular dichroism, and melting temperature measurements. The results indicate that [Ru(bpy) _(3) –GQD] ~(2+) could be intercalated into double stranded DNA. Using [Ru(bpy) _(3) –GQD] ~(2+) as a signal molecule, the charge transfer performance of DNA-intercalated [Ru(bpy) _(3) –GQD] ~(2+) was determined using electrochemical and electrochemiluminescence measurements. Various DNA types were immobilized on Au electrodes via Au–S bonds. Electrochemiluminescence and electrochemical measurements indicate that [Ru(bpy) _(3) –GQD] ~(2+) could enhance DNA-mediated charge transfer when intercalated into an abasic site of double stranded DNA. And comparing with [Ru(bpy) _(3) ] ~(2+) , it can be concluded that GQDs intercalate into the DNA duplex by acting as a base analog, thus enhancing DNA charge transfer. These findings suggest that the DNA–GQD structure could aid the development of molecular devices and electric drivers, and broaden the application of DNA charge transfer.
机译：石墨烯量子点（GQDs）连接到[Ru（bpy）_（3）]〜（2+），以感测DNA介导的电荷转移。通过吸收光谱，凝胶电泳，圆二色性和熔融温度测量研究了无碱基位点双链DNA（Abasic-DNA）和[Ru（bpy）_（3）–GQD]〜（2+）之间的相互作用。结果表明[Ru（bpy）_（3）–GQD]〜（2+）可以插入双链DNA。使用[Ru（bpy）_（3）–GQD]〜（2+）作为信号分子，确定了嵌入DNA的[Ru（bpy）_（3）–GQD]〜（2+）的电荷转移性能。使用电化学和电化学发光测量。各种类型的DNA通过Au–S键固定在Au电极上。电化学发光和电化学测量表明，[Ru（bpy）_（3）–GQD]〜（2+）插入双链DNA的无碱基位点时，可以增强DNA介导的电荷转移。与[Ru（bpy）_（3）]〜（2+）进行比较，可以得出结论，GQD通过充当碱基类似物插入DNA双链体，从而增强了DNA电荷转移。这些发现表明，DNA-GQD结构可以协助分子装置和电驱动器的发展，并扩大DNA电荷转移的应用范围。

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