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Magnetically targeted nanoparticles for imaging-guided photothermal therapy of cancer

机译：磁性靶向纳米粒子用于癌症的成像引导光热疗法

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Over the past several decades, nanocarriers have constituted a vital research area for accurate tumor therapy. Herein, magnetically targeted nanoparticles (IRFes) for photothermal therapy were generated by integrating IR780, a molecule with strong emission and absorption in the NIR spectrum and the ability to produce heat after laser irradiation, with Fe _(3) O _(4) nanoparticles (NPs). These IRFes were guided to the tumor site by the application of an external magnetic field. In particular, the strong NIR absorption of IR780 was used for NIRF imaging, and we also demonstrated effective magnetic targeting for the photothermal ablation of tumors. In vitro cell viability and in vivo antitumor experiments showed that these IRFes can ablate 4T1 cells or transplanted 4T1 cell tumors when exposed to 808 nm laser irradiation and a magnetic field. In vivo experiments showed that IRFes only act on tumors, do not damage other organs and can be used to image tumors. These results demonstrate the enormous potential of local photothermal therapy for cancer under the guidance of external magnetic fields and reveal the prospect for the use of multifunctional nanoparticles in tumor therapy.
机译：在过去的几十年中，纳米载体已成为精确肿瘤治疗的重要研究领域。在此，通过将IR 780与Fe _（3）O _（4）纳米粒子集成在一起，从而生成用于光热治疗的磁性靶向纳米粒子（IRFes） （NP）。通过施加外部磁场将这些IRF引导至肿瘤部位。特别是，IR780的强NIR吸收用于NIRF成像，并且我们还证明了有效的磁靶向技术可用于肿瘤的光热消融。体外细胞生存力和体内抗肿瘤实验表明，当暴露于808 nm激光辐射和磁场中时，这些IRF可以消融4T1细胞或移植的4T1细胞肿瘤。体内实验表明，IRF仅作用于肿瘤，不会损害其他器官，可用于对肿瘤成像。这些结果证明了在外部磁场的指导下局部光热疗法对癌症的巨大潜力，并揭示了在肿瘤疗法中使用多功能纳米粒子的前景。

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