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首页> 外文期刊>RSC Advances >Ultra-performance liquid chromatography/mass spectrometry technology and high-throughput metabolomics for deciphering the preventive mechanism of mirabilite on colorectal cancer via the modulation of complex metabolic networks
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Ultra-performance liquid chromatography/mass spectrometry technology and high-throughput metabolomics for deciphering the preventive mechanism of mirabilite on colorectal cancer via the modulation of complex metabolic networks

机译：超高效液相色谱/质谱技术和高通量代谢组学，通过调节复杂的代谢网络来破译芒硝对结肠直肠癌的预防机制

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摘要

Colorectal cancer (CRC) is a highly virulent and malignant disease and always accompanied by metabolic disorders. Currently, there are no effective therapeutic drugs for the treatment of CRC. High-throughput metabolomics approaches have been used to unveil the metabolic pathways related to several diseases. In this study, ultra-performance liquid chromatography/mass spectrometry-based high-throughput metabolomics was used for deciphering the potential preventive mechanism of mirabilite on CRC via the modulation of the associated metabolic disorders; a total of 28 differential biomarkers, including indole acetaldehyde, 5-hydroxyindoleacetic acid, hypoxanthine, retinal, retinal ester, linoleic acid, stearic acid, 6-deoxocastasterone, 2-hydroxybutyric acid and LysoPC, were identified in the APC ~(min/+) mice. These differential biomarkers are involved in the tryptophan metabolism, glycerophospholipid metabolism and biosynthesis of unsaturated fatty acids. Note that these biomarkers and their disturbed metabolic pathways were also regulated by mirabilite. It has been found that the prevention of CRC by mirabilite is mainly associated with tryptophan metabolism; this study shows that high-throughput metabolomics can reveal the perturbed metabolic disorders targeted in the action mechanism of drug treatment.
机译：大肠癌（CRC）是一种高毒力和恶性疾病，总是伴有代谢紊乱。当前，没有有效的治疗CRC的治疗药物。高通量代谢组学方法已用于揭示与几种疾病相关的代谢途径。在这项研究中，基于超高效液相色谱/质谱的高通量代谢组学被用于通过调节相关的代谢紊乱来研究芒硝对CRC的潜在预防机制。在APC中共鉴定出28种不同的生物标志物，包括吲哚乙醛，5-羟基吲哚乙酸，次黄嘌呤，视网膜，视网膜酯，亚油酸，硬脂酸，6-脱氧基castasterone，2-羟基丁酸和LysoPC。 ） 老鼠。这些差异生物标志物涉及色氨酸代谢，甘油磷脂代谢和不饱和脂肪酸的生物合成。请注意，这些生物标志物及其紊乱的代谢途径也受到芒硝的调控。已经发现，芒硝预防CRC主要与色氨酸代谢有关。这项研究表明，高通量代谢组学可以揭示药物治疗作用机制中靶向的扰动性代谢紊乱。

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