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首页> 外文期刊>RSC Advances >The protective effect of propofol on ionizing radiation-induced hematopoietic system damage in mice
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The protective effect of propofol on ionizing radiation-induced hematopoietic system damage in mice

机译：异丙酚对电离辐射致造血系统损伤的保护作用

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摘要

The hematopoietic system is highly sensitive to ionizing radiation (IR), and IR can cause injury to hematopoietic stem cells (HSCs); the main reason for this may be elevated reactive oxygen species (ROS) levels. Propofol is an anesthetic drug commonly used in clinical practice. The chemical structure of propofol is similar to that of vitamin E, and propofol has an antioxidant capacity. Therefore, in this work the effect of using propofol to protect against IR-induced hematopoietic system injury is evaluated. The data suggested that when the irradiated mice were treated with 20 mg kg ~(?1) of propofol, the survival rate of lethally irradiated mice increased significantly, furthermore, the radiation-induced decrease of white blood cells (WBCs), red blood cells (RBCs), hemoglobin (HGC) and platelets (PLT) in peripheral blood is improved significantly. In addition, propofol could also increase the irradiated HSC and hematopoietic progenitor cell (HPC) frequencies, improving the self-renewal and differentiation abilities of HSCs and HPCs in irradiated mice. Next the ROS levels in HSCs and HPCs were measured, and the results showed that propofol could effectively decrease the ROS levels in these cells. The underlying ROS-scavenging mechanisms are further explored, and the results show that the Nrf2 pathway plays an important role in propofol's radiation protective effects, however, propofol can also increase the proliferation of the Nrf2 inhibitor-treated Lineage ~(?) cells after exposure to 4 Gy radiation. The data suggest that propofol has a radio-protective effect against IR-induced hematopoietic system damage through reducing cellular ROS in HSCs and HPCs partly through the Nrf2 pathway.
机译：造血系统对电离辐射（IR）高度敏感，并且IR可能导致造血干细胞（HSC）受到损伤。造成这种情况的主要原因可能是活性氧（ROS）水平升高。异丙酚是临床实践中常用的麻醉药。异丙酚的化学结构类似于维生素E，并且异丙酚具有抗氧化能力。因此，在这项工作中，评估了使用丙泊酚预防IR引起的造血系统损伤的效果。数据表明，当用20 mg kg〜（？1）异丙酚处理辐照小鼠时，致死辐照小鼠的存活率显着增加，此外，放射诱导的白细胞（WBCs），红细胞减少（RBCs），血红蛋白（HGC）和血小板（PLT）显着改善。另外，丙泊酚还可以增加被照射的HSC和造血祖细胞（HPC）的频率，从而提高被照射的小鼠HSC和HPC的自我更新和分化能力。接下来，测量HSC和HPC中的ROS水平，结果表明丙泊酚可以有效降低这些细胞中的ROS水平。进一步研究了潜在的ROS清除机制，结果表明Nrf2途径在丙泊酚的辐射防护作用中起着重要作用，但是，丙泊酚还可以增加暴露后Nrf2抑制剂处理的Lineage〜（？）细胞的增殖。到4 Gy辐射。数据表明，丙泊酚通过减少HSC和HPC中的细胞ROS的一部分，通过Nrf2途径对IR引起的造血系统损伤具有放射防护作用。

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