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首页> 外文期刊>RSC Advances >Effects and formulation of silver nanoscaffolds on cytotoxicity dependent ion release kinetics towards enhanced excision wound healing patterns in Wistar albino rats
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Effects and formulation of silver nanoscaffolds on cytotoxicity dependent ion release kinetics towards enhanced excision wound healing patterns in Wistar albino rats

机译：纳米银支架对Wistar白化病大鼠细胞毒性依赖的离子释放动力学的影响及增强的伤口愈合方式

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Wound tissue regeneration and angiogenesis are dynamic processes that send physiological signals to the body. Thus, designing novel nanoscaffolds by understanding their surface modifications and toxicological response in a biological system with a potent anti-inflammatory response is a viable solution. In this respect, inspired by the surface chemistry, in the present work we focus on the chemical optimization of silver nanoscaffolds using surface cappings in order to understand their kinetic release behaviour in simulated wound fluids (SWF), to analyze their blood compatibility in human lymphocytes and erythrocytes and then embed them in a chitosan-agarose matrix (CAM) as a productive drug delivery system to evaluate in vivo excision wound tissue regeneration efficiency in Wistar rats. In this regard, polyvinyl alcohol capped silver nanocomposites (PVA-AgNPs) exhibit a dominant antibacterial efficacy with the sustained and controlled release of silver ions and percentage cell mortality and percentage hemolysis of only 10% and 16% compared with uncapped-AgNPs or silver bandaids (SBDs). Also, PVA-AgNP impregnated CAM (PVA-CAM) shows positive effects through their anti-inflammatory and angiogenic properties, with a nearly 95% healing effect within 9 days. The complete development of collagen and fibroblast constituents was also monitored in PVA-CAM by hematoxylinandeosin (HandE) and Masson trichrome (MT) staining. These results provide a clear insight into the development of a potent therapeutic formulation using CAM as a scaffold incorporated with surface functionalized PVA-AgNPs as a bioeffective and biocompatible polymer for the fabrication of efficacious silver wound dressing scaffolds in clinical practice.
机译：伤口组织的再生和血管生成是将生理信号发送到人体的动态过程。因此，通过了解具有有效抗炎反应的生物系统中的表面修饰和毒理学响应来设计新型纳米支架是可行的解决方案。在这方面，受表面化学的启发，在本工作中，我们着重于使用表面盖帽的银纳米支架的化学优化，以了解它们在模拟伤口液（SWF）中的动力学释放行为，以分析它们在人淋巴细胞中的血液相容性和红细胞，然后将其嵌入壳聚糖-琼脂糖基质（CAM）中作为生产性药物传递系统，以评估Wistar大鼠体内切除伤口的组织再生效率。在这方面，聚乙烯醇封端的银纳米复合物（PVA-AgNPs）具有显着的抗菌功效，与未封端的AgNPs或银创可贴相比，银离子的持续和控制释放以及银离子的持续和受控释放以及细胞死亡率和溶血百分比分别仅为10％和16％ （SBD）。而且，PVA-AgNP浸渍的CAM（PVA-CAM）通过其抗炎和血管生成特性显示出积极的作用，在9天内具有近95％的治愈效果。还通过苏木精和曙红（HandE）和Masson三色（MT）染色在PVA-CAM中监测了胶原和成纤维细胞成分的完全发育。这些结果为开发有效的药物制剂提供了清晰的见解，该药物使用CAM作为支架，并结合了表面功能化的PVA-AgNPs，作为在临床实践中制造有效的银伤口敷料支架的生物有效和生物相容性聚合物。

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