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首页> 外文期刊>RSC Advances >Mechanical and thermal properties and cytotoxicity of Al2O3 nano particle-reinforced poly(ether-ether-ketone) for bone implants
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Mechanical and thermal properties and cytotoxicity of Al2O3 nano particle-reinforced poly(ether-ether-ketone) for bone implants

机译：Al2O3纳米颗粒增强聚醚醚酮的骨植入物的力学和热学性质以及细胞毒性

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Weak mechanical properties and mismatching of elastic modulus to human bone restricts the use of PEEK as a bone implant material. By introducing reinforcing particles in polymers, composite material properties could be tailored to meet specific design requirements. In this work, composite materials with PEEK as a matrix and Al _(2) O _(3) as reinforcing fillers were prepared by an injection molding method. Subsequently, the effects of different particle sizes (30 nm, 0.2 μm, 5 μm) and distinct contents (2.5 wt%, 5.0 wt%, 7.5 wt%, 10.0 wt%, 12.5 wt%, 15.0 wt%) of Al _(2) O _(3) powder on the mechanical properties of the composites, such as tensile strength, bending strength, impact strength, Vickers hardness and modulus, were investigated by an electronic universal testing machine. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to compare the thermal properties of composites with different proportions. Besides, the cross-section fractography of the composites after the tensile strength test was characterized by scanning electron microscopy (SEM) to analyze the interface bonding effect. Moreover, mouse fibroblast L929 cells were used for cytotoxicity testing of CCK-8 kit to evaluate cell compatibility of the composite in vitro and cell morphology was observed by inverted fluorescence microscopy. Based on the obtained results, Al _(2) O _(3) reinforcement enhanced many properties in some aspects, which makes the Al _(2) O _(3) /PEEK composite one of the most promising candidates for human bone implantation, reconstruction, orthopedic and trauma applications.
机译：弱的机械性能和弹性模量与人体骨骼的不匹配限制了PEEK作为骨植入材料的使用。通过在聚合物中引入增强颗粒，可以调整复合材料的性能以满足特定的设计要求。在这项工作中，通过注模法制备了以PEEK为基体和Al _（2）O _（3）作为增强填料的复合材料。随后，Al_（）的不同粒径（30 nm，0.2μm，5μm）和不同含量（2.5 wt％，5.0 wt％，7.5 wt％，10.0 wt％，12.5 wt％，15.0 wt％）的影响2）用电子万能试验机研究了O_（3）粉对复合材料力学性能的影响，如拉伸强度，弯曲强度，冲击强度，维氏硬度和模量。使用热重分析（TGA）和差示扫描量热法（DSC）来比较不同比例的复合材料的热性能。此外，通过扫描电子显微镜（SEM）表征了复合材料在拉伸强度试验后的断面形貌，以分析界面结合作用。此外，将小鼠成纤维细胞L929细胞用于CCK-8试剂盒的细胞毒性测试，以评估复合物的体外细胞相容性，并通过倒置荧光显微镜观察细胞形态。根据获得的结果，Al _（2）O _（3）增强材料在某些方面增强了许多性能，这使Al _（2）O _（3）/ PEEK复合材料成为人体骨植入最有希望的候选材料之一，重建，骨科和创伤应用。

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