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Novel fabrication of porous titanium by a resin-impregnated titanium substitution technique for bone reconstruction

机译：通过树脂浸渍钛替代技术新颖地制造多孔钛，用于骨骼重建

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The purpose of this study was to develop a novel porous titanium material with superior mechanical strength and osteoconduction for bone reconstruction. Porous titanium samples were fabricated by titanium-slurry impregnate to prepare urethane forms with several porosities (high-porosity; 92%, middle-porosity; 85% and low-porosity; 65%). Porous HA (mean porosity; 75.3%) was used as a control. To evaluate the characteristics of these materials, we performed porosity measurements, scanning electron microscopy (SEM), three-point bending testing, and cell proliferation assays. To evaluate the osteoconduction ability, porous titanium was placed into the femurs of rabbits and histological and histomorphometric evaluations were performed after 3 weeks. In SEM images, porous three-dimensional structures were observed in all samples. The bending strength significantly increased as porosity increased (Ti-65 > Ti-85 > porous HA > Ti-92, P < 0.05; respectively). Ti-65, Ti-85, and porous HA showed good cell proliferation. Newly formed bone was observed in the central portion of Ti-65, Ti-85, and porous HA. Ti-92 was mainly detected in the bone marrow tissue. The bone formation areas of Ti-65, Ti-85, and porous HA were significantly higher than that of Ti-92 ( P < 0.05). It was suggested that novel developed porous titanium composed of Ti-65 and Ti-85 showed superior mechanical strength and osteoconduction.
机译：这项研究的目的是开发一种具有优异机械强度和骨传导性的新型多孔钛材料，用于骨骼重建。通过浸渍钛浆制备多孔钛样品，以制备具有多种孔隙度（高孔隙度; 92％，中孔隙度; 85％和低孔隙度; 65％）的氨基甲酸酯形式。多孔HA（平均孔隙度; 75.3％）用作对照。为了评估这些材料的特性，我们进行了孔隙率测量，扫描电子显微镜（SEM），三点弯曲测试和细胞增殖分析。为了评估骨传导能力，将多孔钛放入兔股骨中，并在3周后进行组织学和组织形态学评估。在SEM图像中，在所有样品中均观察到多孔的三维结构。弯曲强度随孔隙率的增加而显着增加（分别为Ti-65> Ti-85>多孔HA> Ti-92，P <0.05;）。 Ti-65，Ti-85和多孔HA显示出良好的细胞增殖。在Ti-65，Ti-85和多孔HA的中央部分观察到新形成的骨骼。 Ti-92主要在骨髓组织中检测到。 Ti-65，Ti-85和多孔HA的骨形成面积显着高于Ti-92（P <0.05）。提出了由Ti-65和Ti-85组成的新型开发的多孔钛表现出优异的机械强度和骨传导性。

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