Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione

Akira Ono; Takahiro Atsugi; Misato Goto; Hisao Saneyoshi; Takahito Tomori; Kohji Seio; Takenori Dairaku; Jiro Kondo

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Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione

机译：通过6-硫鸟嘌呤–6-硫鸟嘌呤二硫键交联的DNA双链体的晶体结构：Cu（ii）离子和谷胱甘肽催化的可逆形成和裂解

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Herein, we determined the crystal structure of a DNA duplex containing consecutive 6-thioguanine–6-thioguanine disulfides. The disulfide bonds were reversibly formed and cleaved in the presence of Cu( II ) ions and glutathione. To our knowledge, this is the first reaction in which metal ions efficiently accelerated disulfide bond formation between thio-bases in duplexes.

机译：在这里，我们确定了包含连续的6-硫鸟嘌呤-6-硫鸟嘌呤二硫化物的DNA双链体的晶体结构。在Cu（II）离子和谷胱甘肽的存在下可逆地形成并裂解了二硫键。据我们所知，这是第一个反应，其中金属离子有效地加速了双链体中硫基之间的二硫键形成。

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《RSC Advances》 |2019年第40期|共4页
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Akira Ono; Takahiro Atsugi; Misato Goto; Hisao Saneyoshi; Takahito Tomori; Kohji Seio; Takenori Dairaku; Jiro Kondo;
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1. Crystal structure of a DNA duplex cross-linked by 6-thioguanine-6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione [J] . Ono Akira, Atsugi Takahiro, Goto Misato, RSC Advances . 2019,第40期

机译：DNA双相的晶体结构通过6-thioguanne-6-thioguanine二硫化物交联：Cu（II）离子和谷胱甘肽催化的可逆形成和裂解
2. 6-Thioguanine alters the structure and stability of duplex DNA and inhibits quadruplex DNA formation. [J] . Marathias VM, Sawicki MJ, Bolton PH Nucleic Acids Research . 1999,第14期

机译：6-硫鸟嘌呤改变了双链体DNA的结构和稳定性，并抑制了四链体DNA的形成。
3. 6-Thioguanine alters the structure and stability of duplex DNA and inhibits quadruplex DNA formation [J] . Michele J. Sawicki, Philip H. Bolton, Vasilios M. Marathias Nucleic acids research . 1999,第14期

机译：6-硫鸟嘌呤改变双链体DNA的结构和稳定性并抑制四链体DNA的形成
4. Preparation of Disulfide Cross-Linked Hydrogels Based on Sodium Alginate and their pH- and Glutathione-Sensitivity [C] . Jianbo Feng, Ting Liu, Ke Shu Louisiana Meeting . 2013

机译：基于藻酸钠及其pH-和谷胱甘肽敏感性制备二硫化物交联水凝胶
5. Part I: Radical cation propagation through bulged and mis-paired DNA: "A purine:purine staggered walk". Part II: Bulged DNA cleavage via a "classic intercalator": A surprising role for singlet-excited ethidium bromide in the selective cleavage of a G-bulge containing duplex. Part III: Synthesis and photochemical behavior of peptide nucleic acid trimers containing benzamidonaphthalimide. [D] . Boone, Edna Karen. 2001

机译：第一部分：通过凸起和错误配对的DNA进行的自由基阳离子传播：“嘌呤：嘌呤错开行走”。第二部分：通过“经典嵌入剂”进行的DNA裂解：单线态激发的溴化乙锭在选择性裂解含G-双链的双链体中的出奇作用。第三部分：含有苯甲酰胺基萘二甲酰亚胺的肽核酸三聚体的合成和光化学行为。
6. 6-Thioguanine alters the structure and stability of duplex DNA and inhibits quadruplex DNA formation. [O] . V M Marathias, M J Sawicki, P H Bolton 1999

机译：6-硫鸟嘌呤改变了双链体DNA的结构和稳定性并抑制了四链体DNA的形成。
7. Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione [O] . Akira Ono, Takahiro Atsugi, Misato Goto, 2019

机译：DNA双相的晶体结构通过6-thioguanne-6-thioguanine二硫化物交联：Cu（II）离子和谷胱甘肽催化的可逆形成和裂解
8. CU(II) Catalyzed Hydrolysis of an Unactivated Ester Based on Reversible ConjugateAddition [R] . Duerr, B. F., Czarnik, A. W. 1990

机译：基于可逆共轭加成的CU（II）催化的未活化酯的水解

Crystal structure of a DNA duplex cross-linked by 6-thioguanine–6-thioguanine disulfides: reversible formation and cleavage catalyzed by Cu(ii) ions and glutathione

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