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首页> 外文期刊>RSC Advances >Enhancement effect of reduced graphene oxide and silver nanocomposite supported on poly brilliant blue platform for ultra-trace voltammetric analysis of rosuvastatin in tablets and human plasma
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Enhancement effect of reduced graphene oxide and silver nanocomposite supported on poly brilliant blue platform for ultra-trace voltammetric analysis of rosuvastatin in tablets and human plasma

机译：聚艳蓝平台上负载的还原型氧化石墨烯和银纳米复合材料对瑞舒伐他汀片剂和人血浆中超痕量伏安分析的增强作用

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The enhancement effect of reduced graphene oxide (rGO) combined with silver nanocomposite supported on poly brilliant blue (PBB) platform was investigated for ultra-trace analysis of rosuvastatin (RS). Herein, in situ electrochemical deposition of the silver nanoparticles (AgNPs) and rGO hybrid was performed on the surface of the polymerized brilliant blue (PBB) platform. The developed (AgNPs–rGO/PBB) electrode showed an enhanced catalytic activity toward the oxidation of RS. The modified electrodes AgNPs–rGO/PBB and AgNPs/PBB required an overpotential of 0.68 and 1.06 V to achieve a current density of 10 mA cm ~(?2) , and their corresponding Tafel slopes were calculated to be 70 and 105 mV dec ~(?1) , respectively. Further, rGO and silver nanocomposites properties were characterized by scanning electron microscopy (SEM), cyclic voltammetry (CV), square wave voltammetry (SWV), linear sweep voltammetry (LSV), and electrochemical impedance spectroscopy (EIS). Additionally, the formation of GO and AgNPs–rGO was confirmed by Raman spectroscopy and Fourier transform infrared spectroscopy (FT-IR). Under the optimized conditions, the electrochemical sensor showed a remarkable response for quantitation of RS over a wide range of concentrations 5 × 10 ~(?9) to 5 × 10 ~(?7) mol L ~(?1) ( r = 0.9988), with a limit of detection 2.17 × 10 ~(?9) mol L ~(?1) . The electrochemical performance of the studied electrode showed high reproducibility and suitability for tablets and human plasma.
机译：为了研究瑞舒伐他汀（RS）的超痕量分析，研究了还原氧化石墨烯（rGO）结合在聚亮蓝色（PBB）平台上负载的银纳米复合材料的增强效果。在此，在聚合的亮蓝（PBB）平台的表面上进行了银纳米颗粒（AgNPs）和rGO杂化物的原位电化学沉积。发达的（AgNPs–rGO / PBB）电极对RS的氧化表现出增强的催化活性。修饰电极AgNPs–rGO / PBB和AgNPs / PBB需要0.68和1.06 V的超电势才能实现10 mA cm〜（？2）的电流密度，并且计算出它们相应的Tafel斜率dec〜70和105 mV dec〜 （？1）。此外，rGO和银纳米复合材料的性能通过扫描电子显微镜（SEM），循环伏安法（CV），方波伏安法（SWV），线性扫描伏安法（LSV）和电化学阻抗谱（EIS）进行表征。此外，GO和AgNPs-rGO的形成已通过拉曼光谱和傅立叶变换红外光谱（FT-IR）得以证实。在优化的条件下，电化学传感器在5×10〜（？9）到5×10〜（？7）mol L〜（？1）的宽浓度范围内对RS定量显示出显着的响应（r = 0.9988 ），检出限为2.17×10〜（？9）mol L〜（？1）。所研究电极的电化学性能显示出对片剂和人体血浆的高重现性和适用性。

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