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首页> 外文期刊>RSC Advances >Ultrasound assisted one-step synthesis of Au@Pt dendritic nanoparticles with enhanced NIR absorption for photothermal cancer therapy
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Ultrasound assisted one-step synthesis of Au@Pt dendritic nanoparticles with enhanced NIR absorption for photothermal cancer therapy

机译：超声辅助一步合成Au @ Pt树突状纳米粒子，具有增强的近红外吸收，可用于光热癌症治疗

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Near-infrared (NIR) light-mediated non-invasive photothermal therapy (PTT) has attracted considerable attention for cancer treatment. Strong optical absorption located in the NIR region and high performance in converting light to heat should be emphasized for the development of ideal photothermal agents. In this report, Au@Pt bimetallic nanoparticles (Au@Pt NPs) with dendritic structure were synthesized through an ultrasound assisted one-step method in aqueous solution. The absorption of Au@Pt NPs at 808 nm was obviously enhanced compared to that of Au NPs and could be easily manipulated via the amount of Pt NPs. Au@Pt NPs exhibited excellent photostability with a photothermal conversion efficiency of 44.2%, which is significantly higher than those in most reported studies. Au@Pt NPs with thiol PEG functionalization presented improved cellular killing capacity upon NIR laser irradiation. Moreover, the potential application of Au@Pt NPs was also investigated in xenograft tumor mouse model. Overall, the remarkable therapeutic characteristics of PEGylated Au@Pt NPs provide them with great potential for future cancer treatment.
机译：近红外（NIR）光介导的非侵入性光热疗法（PTT）已引起癌症治疗的广泛关注。为了开发理想的光热剂，应强调位于NIR区域的强光吸收和将光转换为热的高性能。在本报告中，通过超声辅助一步法在水溶液中合成了具有树枝状结构的Au @ Pt双金属纳米颗粒（Au @ Pt NPs）。与Au NPs相比，Au @ Pt NPs在808 nm处的吸收明显增强，并且可以通过Pt NPs的量容易地控制。 Au @ Pt NPs具有出色的光稳定性，光热转换效率为44.2％，大大高于大多数报道的研究。具有硫醇PEG功能化的Au @ Pt NPs在近红外激光照射下具有更高的细胞杀伤能力。此外，还研究了Au @ Pt NPs在异种移植肿瘤小鼠模型中的潜在应用。总体而言，聚乙二醇化的Au @ Pt NP的显着治疗特性为其未来的癌症治疗提供了巨大潜力。

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