• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>RSC Advances >Surface-attached sulfonamide containing quaternary ammonium antimicrobials for textiles and plastics
【24h】

Surface-attached sulfonamide containing quaternary ammonium antimicrobials for textiles and plastics

机译：纺织品和塑料的表面附着的含磺酰胺季铵抗微生物剂

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

With the risks associated with healthcare-associated infections and the rise of antibiotic resistant microorganisms, there is an important need to control the proliferation of these factors in hospitals, retirement homes and other institutions. This work explores the development and application of a novel class of sulfonamide-based quaternary ammonium antimicrobial coatings, anchored to commercially and clinically relevant material surfaces. Synthesized in high yields (60–97%), benzophenone-anchored antimicrobials were spray-coated and UV grafted onto plastic surfaces, while silane-anchored variants were adhered to select textiles via dip-coating. Surface modified samples were characterised by advancing contact angle, anionic dye staining, X-ray photoelectron spectroscopy and atomic force microscopy. After verifying coating quality through the above characterization methods, microbiological testing was performed on batch samples in conditions that simulate the natural inoculation of surfaces and objects (solid/air) and water containers (solid/liquid). Using the previously established Large Drop Inoculum (LDI) protocol at solid/air interfaces, all treated samples showed a full reduction (10 ~(5) –10 ~(7) CFU) of viable Arthrobacter sp., S. aureus , and E. coli after 3 h of contact time. Additional testing of the walls of plastic LDPE vials treated with a UV-cured sulfonamide antimicrobial at a solid/liquid interface using the newly developed Large Reservoir Inoculum (LRI) protocol under static conditions revealed a complete kill (>10 ~(6) reduction) of Gram-positive Arthrobacter sp., and a partial kill (>10 ~(4) reduction) of Gram-negative E. coli within 24–48 h of contact.
机译：由于存在与医疗保健相关的感染相关的风险以及对抗生素具有抗药性的微生物的兴起，因此非常需要控制这些因素在医院，养老院和其他机构中的扩散。这项工作探索了锚固在商业和临床相关材料表面上的新型基于磺酰胺的季铵抗菌涂层的开发和应用。以高产率（60-97％）合成后，将苯甲酮锚定的抗菌剂喷涂并在塑料表面进行紫外线接枝，而硅烷锚定的变体则通过浸涂法粘附到选定的纺织品上。表面改性的样品的特征在于前进的接触角，阴离子染料染色，X射线光电子能谱和原子力显微镜。通过上述表征方法验证涂层质量后，在模拟表面和物体（固体/空气）和水容器（固体/液体）自然接种的条件下，对批次样品进行了微生物测试。使用先前在固体/空气界面上建立的大滴度接种物（LDI）协议，所有处理过的样品均显示出活节杆菌，金黄色葡萄球菌和大肠杆菌完全减少（10〜（5）–10〜（7）CFU）接触时间3小时后出现大肠杆菌。使用新开发的大型水库接种物（LRI）协议在静态条件下在固/液界面对经过UV固化的磺酰胺抗菌剂处理的塑料LDPE小瓶的壁进行额外测试，发现其完全杀灭（减少了10〜（6））。在接触后24-48小时内，革兰氏阳性节肢杆菌的数量减少，革兰氏阴性大肠杆菌被部分杀死（> 10〜（4）降低）。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号