Supplementary data are presented concerning the metabolic and physical status of a boy with apparent mixed adrenal cortical disease. These data suggest that he has been suffering from (a) at least a relative deficiency of the adrenal cortical Na-K regulating hormone and (b) both a relative and absolute excess of adrenal cortical androgens. It appears that the adrenal cortical sugar-fat-nitrogen regulating hormones were being produced in approximately normal amounts. The excess androgen production was associated with hyperplasia of adrenal cortical zona reticularis-like cells located both in the adrenals and the testes. It is suggested that the hyperplasia was the result of excess stimulation by adrenocorticotropic hormone. The effects of these derangements upon the patient's growth and development are described.
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