Data has been presented showing that, although 4 months after the third injection of poliomyelitis vaccine, antibody levels were quite high, at 12 months there was a definite and striking decrease in antibody titers.It is suggested that serious consideration be given to the routine administration of a fourth, 1-ml, injection of poliomyelitis vaccine 12 months after the third injection.It would seem advisable to follow this practice unless it can be demonstrated that the state and degree of hypersensitivity, without detectable antibodies, is sufficiently great to result in a protective response when natural infection occurs.
展开▼
