Premature infants who received more than ACTH 5 mg./kg./day became hyperirritable and ravenous. Many became pallid immediately after injection of the hormone. During the course of treatment infections which appeared could be controlled with antibacterial therapy.Untreated premature infants excreted increasing amounts of chemically assayed urinary "corticosteroids" with increased body weight. Under the influence of doses of ACTH in excess of 5 mg./kg./day the urinary excretion of "corticosteroids" increased significantly.Retardation of growth occurred during the administration of more than 5 mg. ACTH/ kg./day. "Rebound" increase in growth took place upon cessation of hormonal administration.
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