The clinical features of diabetes insipidus are described in a family showing dominant inheritance of this condition. Forty affected individuals in six generations are listed. Two members of the family, investigated in hospital, showed no alteration of urinary flow in response to the intravenous injection of saline, but a marked reduction in flow following the injection of pitressin, thus confirming the diagnosis of diabetes insipidus due to pitressin deficiency. An exceedingly great urinary output is not necessarily a feature of the disease. The diagnostic value of the family history is emphasized.
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