The response of hypertension occurring in acute nephritis in children to apresoline? has been studied. Significant temporary reductions in elevated blood pressure were produced by parenteral and oral apresoline? in 5 of 7 children with acute nephritis. The effect of this agent in two patients with hypertension and chronic renal disease was less impressive.Studies of changes in renal function following parenteral administration of apresoline? were made in seven children with acute nephritis. Significant temporary depressions of the glomerular filtration rate and urine flow were observed in every instance in which apresoline? induced a fall in systemic blood pressure.Apresoline? did not regularly induce an increase in renal plasma flow in these subjects. Changes in renal plasma flow were variable, and even decreases were observed. Even though apresoline? can induce a fall in blood pressure in children with hypertension and acute nephritis, this response may be associated with a temporary depression in renal excretory function.
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