An 8-year-old boy with chronic granulomatous disease (CGD) was admitted in moribund condition with aspergillus pneumonia. Because of the gravity of the situation, normal granulocyte infusions were used as adjuncts to the more conventional antimicrobial therapy. White blood cells, derived from a total of 58 units of whole blood obtained by leukophoresis of the father, were given in two separate doses. The first dose, totaling 2.8 x 1010 granulocytes, was coincident with significant improvement, and the second, totaling 3.0 x 1010 granulocytes, was coincident with the onset of clinical improvement and interim recovery. Transient improvement in in vitro granulocyte function was noted in cells taken from the patient's blood immediately after infusion. No adverse effects of the infusions were noted in either the patient or the donor. Although it is impossible to divorce the therapeutic effect of the granulocyte infusions from the more conventional therapy, we conclude that normal granulocyte infusions can be considered a valid adjunct in children with CGD who are suffering from a life-threatening infection.
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机译：一名患有慢性肉芽肿性疾病（CGD）的8岁男孩因垂死病情而患有曲霉菌性肺炎。由于情况的严重性，正常的粒细胞输注被用作更常规抗微生物治疗的辅助手段。白血球以两次单独的剂量给药，该白血球是通过父亲白细胞电泳获得的，共计58单位全血。第一个剂量总计2.8 x 1010粒细胞，与重大改善相吻合，第二个剂量总计3.0 x 1010粒细胞，与临床改善和中期恢复相吻合。输注后立即从患者血液中采集的细胞中发现了体外粒细胞功能的短暂改善。在患者或供体中均未观察到输注的不良影响。尽管不可能将粒细胞输注的治疗效果与更传统的治疗方法相提并论，但我们得出的结论是，正常粒细胞输注可以视为患有致命性感染的CGD儿童的有效辅助治疗。
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