The physiologic and psychological responses to androgen treatment of constitutional delay of growth and development were prospectively evaluated in 16 male adolescents, aged 14 to 17 years. Subjects were randomly assigned to a course of testosterone enanthate, 200 mg administered intramuscularly four times at three-week intervals or to observation. At one-year follow-up all subjects in the testosterone group exhibited excellent growth: 7.2 to 11.6 cm/yr (mean 9.2 cm/yr). Growth in control subjects was highly variable: 2.6 to 10.6 cm/yr (mean 6.0 cm/yr), significantly lower than that of the testosterone group ( P .02). The mean annual increment in bone age was 1.1 years for both groups. The Δ height age/Δ bone age ratio was slightly higher in the testosterone group (1.3 vs 1.1), and the treated subjects had a 1.7-cm increase in predicted adult height. Both groups showed improved self-image, and treated subjects also exhibited dramatic increases in both school-related and extraschool social activity. A brief course of testosterone enanthate appears to be an effective, safe means of promoting growth in select male adolescents.
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机译：前瞻性评估了年龄在14至17岁之间的16名男性青少年对雄激素治疗体质性生长和发育延迟的生理和心理反应。将受试者随机分配给一个疗程的睾丸激素庚酸酯，每三周间隔两次肌肉注射200 mg，或进行观察。在一年的随访中，睾丸激素组的所有受试者均表现出出色的生长：7.2至11.6厘米/年（平均9.2厘米/年）。对照受试者的生长变化很大：2.6至10.6 cm / yr（平均6.0 cm / yr），显着低于睾丸激素组（P <.02）。两组的平均骨龄年均增长为1.1岁。睾丸激素组的Δ高度年龄/Δ骨年龄比略高（1.3比1.1），并且接受治疗的受试者的成人预期身高增加了1.7 cm。两组的自我形象都有改善，接受治疗的受试者在与学校有关的活动和校外社交活动中也都有显着增加。短暂服用睾丸激素庚酸酯似乎是一种促进选定男性青少年生长的有效，安全的方法。
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