Taurine and cholesterol are constituents of human milk that are present in smaller amounts in infant formulas. Infants fed such formulas have lower plasma and urine concentrations of taurine and of serum total cholesterol. In the present investigation, in infants of 31 to 36 weeks gestational age, the effects of supplementing a 1.5 g/100 mL whey-predominant formula with taurine alone or with taurine plus cholesterol were examined. Infants fed the supplemented formula were compared with infants fed the unsupplemented formula and with infants fed pooled, expressed human milk (185 mL/kg/d). Approximately 45% of the human milk provided to each infant was that of the infant's mother (35% pasteurized and 10% fresh). From the time of reaching a weight of 2,400 g to 4 months of age the last group of infants was fed ad libitum. No consistent statistically significant differences in growth, as measured by rate of gain in crown-rump length, crown-heel length, or head circumference, were observed. There was a tendency, however, for the formula-fed infants to gain weight more slowly before reaching 2,400 g and to gain weight more quickly after a weight of 2,400 g was attained to 4 months of age. No differences in concentrations of BUN, total serum proteins or acid-base status were observed among the formula-fed groups. The concentration of BUN increased in the formula-fed groups compared with the group fed human milk during the last half of the study. The formula-fed infants tended to have higher total serum proteins and to be slightly more acidotic than the infants fed human milk prior to discharge at a weight of 2,400 g but not thereafter. Thus, infants fed 185 mL/kg/d gained weight at rates comparable to those for fetuses of the same gestational age. Supplementation of formulas with taurine or taurine plus cholesterol did not produce changes in growth or general metabolism discernible under the present experimental conditions.
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机译：牛磺酸和胆固醇是母乳的成分，在婴儿配方食品中含量较小。用这种配方食品喂养的婴儿血浆和尿液中牛磺酸和血清总胆固醇的浓度较低。在本研究中，研究了在胎龄为31至36周的婴儿中，单独牛磺酸或牛磺酸加胆固醇补充1.5 g / 100 mL乳清为主的配方奶的效果。将喂食补充配方奶粉的婴儿与喂食未补充配方奶粉的婴儿以及混合喂养的表达母乳（185 mL / kg / d）婴儿进行比较。提供给每个婴儿的母乳中大约有45％是婴儿母亲的母乳（巴氏杀菌35％，新鲜10％）。从体重达到2400克到4个月大时，最后一组婴儿被随意喂养。没有观察到一致的统计学上显着的生长差异，用冠臀长度，冠跟长度或头围的增加率来衡量。但是，配方奶喂养的婴儿有一种趋势，在达到2400克之前体重增长较慢，在达到4400个月的体重后体重增长更快。在配方食品喂养的组之间，未观察到BUN浓度，总血清蛋白或酸碱状态的差异。在研究的后半段期间，配方奶喂养的组中的BUN浓度与饲喂母乳的组相比有所增加。与在以2400 g体重排出但在此之后没有排出母乳之前喂食人乳的婴儿相比，配方奶喂养的婴儿往往具有更高的总血清蛋白，并且酸中毒程度略高。因此，以185 mL / kg / d喂养的婴儿体重增加的速度与相同胎龄的婴儿相当。在目前的实验条件下，补充牛磺酸或牛磺酸加胆固醇的配方食品不会产生生长或一般代谢的变化。
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