Fifty newborn infants of less than 33 weeks' gestation were followed prospectively from birth to evaluate the temporal relationships of various clinical factors to the onset and progression of intracranial hemorrhage (ICH) in an inborn population given maximal support. ICH was diagnosed and followed with bedside ultrasound every eight hours. The incidence of intraventricular hemorrhage was 30% and of any ICH was 40% with onset from less than 2 hours to 8 days of age. Grades 2, 3, and 4 ICH correlated with Apgar scores of less than 5 at five minutes, vaginal delivery, longer labors, and intrapartum hemorrhage. There was a significant correlation between ICH and both blood pressure fluctuations of greater than 100% and rapid colloid infusions. Slow transfusions of packed red cells did not appear to precipitate episodes of ICH. In a setting of optimal care, ICH appears to be more related to prenatal stresses than to specific postnatal complications.
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机译：从出生开始前瞻性地追踪了50名小于33周妊娠的新生儿，以评估各种临床因素与获得最大支持的先天人群颅内出血（ICH）发作和进展的时间关系。诊断为ICH，每8小时进行床旁超声检查。脑室出血的发生率为30％，ICH的发病率为40％，发病年龄小于2小时至8天。 ICH 2级，3级和4级与五分钟内的Apgar得分低于5，阴道分娩，更长的分娩时间和产时出血相关。 ICH与血压波动大于100％和快速注入胶体之间存在显着相关性。充血的红细胞缓慢输注似乎未引起ICH发作。在最佳护理条件下，ICH与产前压力的关系比与特定的产后并发症的关系更大。
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