The 24-hour integrated concentration of growth hormone from 46 children of normal stature was compared with that of 90 short children. Nineteen of the short children had classic growth hormone deficiency by standard pharmacologic growth hormone stimulation tests. Seventy-one children had normal growth hormone responses to stimulation. The mean integrated concentration of growth hormone for children with normal stature (6.6 ± 1.9 ng/mL) was greater than the mean value for those with normal stimulated growth hormone (3.8 ± 2.3 ng/mL) and greater than the mean value for those with growth hormone deficiency (1.6 ± 0.6 ng/mL); differences between groups were all statistically significant ( P .0001). Forty-five percent of children with normal stimulated growth hormone responses had integrated concentration of growth hormone within the range of values for the group with growth hormone deficiency; this finding may provide the explanation for their poor growth. Thus, patients with normal growth hormone responses have a spectrum of spontaneous growth hormone secretion ranging from normal to impaired. Recent reports indicate that children with normal growth hormone responses who have very low integrated concentration of growth hormone may have the potential to improve their growth with growth hormone therapy. Therefore, use of the integrated concentration of growth hormone may be a more effective method than standard pharmacologic stimulation tests for determining which short children are potentially able to respond to growth hormone therapy.
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机译：比较了46名正常身高儿童的90小时生长激素的24小时综合浓度。通过标准药理生长激素刺激试验，其中有19个矮小的孩子患有经典的生长激素缺乏症。七十一名儿童对刺激的生长激素反应正常。身高正常儿童的平均生长激素综合浓度（6.6±1.9 ng / mL）大于正常刺激儿童的平均生长激素浓度（3.8±2.3 ng / mL），大于身高正常儿童的平均值。生长激素缺乏症（1.6±0.6 ng / mL）;两组之间的差异均具有统计学意义（P <.0001）。在正常的生长激素刺激反应中，有45％的儿童的生长激素综合浓度在生长激素缺乏症组的数值范围内。这一发现可能为它们的不良增长提供了解释。因此，生长激素反应正常的患者自发性生长激素分泌范围从正常到受损。最近的报告表明，生长激素综合浓度非常低的生长激素反应正常的儿童可能通过生长激素疗法有可能改善其生长。因此，使用生长激素的综合浓度可能是一种比标准药理刺激试验更有效的方法，以确定哪些矮个子儿童可能会对生长激素治疗产生反应。
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