We investigated the influence of human milk protein and medium-chain triglyceride supplementations of human milk feedings on the growth of very low birth weight infants during their first weeks of life. A group of 44 preterm infants with birth weights of less than 1,520 g and a mean gestational age of 30.3 weeks was randomly divided into four groups to receive plain human milk or human milk supplemented with human milk protein (0.9 g/dL), with medium-chain triglycerides (1 g/dL), or with both. The medium-chain triglyceride oil supplementation did not influence the growth of these infants. The infants given supplementary protein gained weight faster during weeks 4 to 6 than those without (18.5 ± 0.7 v 15.1 ± 0.6 g/kg/d; mean ± SEM; P = .001). After 4 weeks of age the infants given supplementary protein had a mean weight gain equal to the mean intra-uterine rate, in contrast to the infants of the other groups, who grew more slowly until age 6 weeks. Furthermore, we found a correlation between serum albumin concentration and weight gain during the seventh week of life ( P = .018). The length growth velocity for the infants with protein supplementation was 0.99 ± 0.06 cm/wk (mean ± SEM) and for those without 0.83 ± 0.05 cm/wk ( P = .043). There was no difference in growth of head circumference between the groups. We conclude that human milk protein supplementation improves the growth of small premature infants fed human milk, and that the protein concentration of bank milk is insufficient for their adequate growth.
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机译：我们研究了人乳蛋白和人乳喂养中链甘油三酸酯补充剂对极低出生体重婴儿出生后第一周的生长的影响。将44例出生体重小于1,520 g且平均胎龄为30.3周的早产婴儿随机分为四组，分别接受纯牛奶或补充了人乳蛋白（0.9 g / dL）的人乳， -链甘油三酸酯（1 g / dL），或两者兼而有之。中链甘油三酸酯油补充剂不会影响这些婴儿的生长。服用补充蛋白质的婴儿在第4至6周内的体重增加比不服用补充蛋白质的婴儿快（18.5±0.7 v 15.1±0.6 g / kg / d;平均值±SEM; P = .001）。在4周龄后，接受补充蛋白的婴儿的平均体重增加等于平均子宫内率，而其他组的婴儿直到6周龄才生长缓慢。此外，我们发现在生命的第七周内血清白蛋白浓度与体重增加之间存在相关性（P = .018）。补充蛋白质的婴儿的身长生长速度为0.99±0.06 cm / wk（平均值±SEM），而不含蛋白质的婴儿的身长生长速度为0.83±0.05 cm / wk（P = .043）。两组之间头围的生长没有差异。我们得出的结论是，补充人乳蛋白质可改善喂食人乳的早产儿的生长，而母乳中蛋白质的浓度不足以使其充分生长。
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