Purpose of the Study. To determine the effects of therapeutic β2 agonists (specifically salbutamol) on growth hormone (GH) response to growth hormone releasing hormone (GHRH) in children with asthma.Study Population. Fifteen prepubertal children with asthma, ages 6-11 (average age of 9) with normal or normal short stature were studied. Those with an endocrine abnormality, nutritional deficiency, psychological deprivation, or other systemic disease were excluded. Only those children with known bronchial asthma, who showed a 15% decrease of the 1-second forced expiratory volume (FEV1) with methacholine challenge were included. All patients were asymptomatic, and had not experienced an asthma exacerbation, respiratory infection or allergen exposure in the month preceding the study. No child was on medications.Methods. Subjects were divided into two groups. Both groups had baseline GH response to GHRH determined. After an overnight fast, GH levels were obtained the following morning at -60, 0, and then every 15 minutes until 120 minutes after GHRH administration. Two days following this, Group A received salbutamol (0.125 mg/kg) orally at -60 minutes and GH response to GHRH was remeasured. Group B received aerosolized salbutamol (2 mg over 15 minutes) (details of administration were not specified by the authors). All serum GH levels were measured in duplicate by immunoradiometric assay (sensitivity of 0.1 μg/L).Findings. Basal GH levels were similar in both groups. Orally administered salbutamol (Group A) markedly inhibited GH response to GHRH (peak of 3.7 ± 0.6 vs. 18.6 ± 4.7 g/L). Inhaled salbutamol (Group B), although blunting the GHRH-induced GH response, did so to a lesser extent (peak of 20.0 ± 7.5 vs. 35.8 ± 9.4 g/L, P .02).
展开▼
机译：这项研究的目的。为了确定治疗性β2激动剂（特别是沙丁胺醇）对哮喘患儿生长激素（GH）对生长激素释放激素（GHRH）的反应的影响，研究人群。研究了十五名青春期前哮喘儿童，他们的身高正常或正常矮小，年龄为6-11岁（平均年龄为9岁）。排除那些患有内分泌异常，营养缺乏，精神剥夺或其他全身性疾病的患者。仅包括那些患有已知支气管哮喘的儿童，他们在服用乙酰甲胆碱后的1秒强迫呼气量（FEV1）降低了15％。所有患者均无症状，并且在研究前一个月中未经历哮喘急性发作，呼吸道感染或过敏原暴露。没有孩子服用药物。方法。受试者分为两组。两组均确定了对GHRH的基线GH反应。在过夜禁食后，第二天早晨在-60、0，然后每15分钟直到GHRH施用后120分钟获得GH水平。此后两天，A组在-60分钟时口服沙丁胺醇（0.125 mg / kg），并重新测量了对GHRH的GH反应。 B组接受雾化的沙丁胺醇（15分钟内2毫克）（作者未指定给药细节）。通过免疫放射测定法一式两份测量所有血清GH水平（敏感性为0.1μg/ L）。两组的基础GH水平相似。口服沙丁胺醇（A组）显着抑制了GH对GHRH的反应（峰值为3.7±0.6对18.6±4.7 g / L）。吸入沙丁胺醇（B组）虽然减弱了GHRH诱导的GH反应，但程度较轻（峰值为20.0±7.5 vs. 35.8±9.4 g / L，P <.02）。
展开▼
