BRONCHIAL BIOPSY EVIDENCE FOR LEUKOCYTE INFILTRATION AND UPREGULATION OF LEUKOCYTE-ENDOTHELIAL CELL ADHESION MOLECULES 6 HOURS AFTER LOCAL ALLERGEN CHALLENGE OF SENSITIZED ASTHMATIC AIRWAYS
Endobronchial allergen challenge in allergic asthmatics leads to a decrease in pulmonary function, and an increase in bronchial hyperresponsiveness within 24 hours, and an influx of inflammatory cells (neutrophils, eosinophils, mast cells, and lymphocytes) within 6 hours. In addition, 6 hours postallergen challenge, an increase was detected in the expression of several endothelial cell adhesion molecules (ICAM, E-selectin), which are essential for inflammatory cell migration.
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