OBJECTIVE. The goal was to assess the association of metabolic syndrome in childhood with adult cardiovascular disease 25 years later.METHODS. Data from the National Heart, Lung, and Blood Institute Lipid Research Clinics Princeton Prevalence Study (1973–1976) and the Princeton Follow-up Study (2000–2004) were used. BMI was used as the obesity measure in childhood, because waist circumference was not measured in the Lipid Research Clinics study. The adult cardiovascular disease status of participants and their parents was obtained through participant report. A logistic analysis was used to predict adult cardiovascular disease; pediatric metabolic syndrome, age at the Princeton Follow-up Study, gender, race, and parental history of cardiovascular disease were potential explanatory variables.RESULTS. Ages ranged from 6 to 19 years in the Lipid Research Clinics study and from 30 to 48 years in the Princeton Follow-up Study. There were 17 cases of cardiovascular disease in the analysis cohort in the Princeton Follow-up Study. Pediatric metabolic syndrome and age at follow-up assessment were significant predictors of cardiovascular disease. Pediatric metabolic syndrome and changes in age-specific BMI percentile from childhood to adulthood were significant predictors of adult metabolic syndrome.CONCLUSIONS. Evaluating children for metabolic syndrome could identify patients at increased risk of adult cardiovascular disease, making targeted interventions possible.
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机译：目的。目的是评估25年后儿童代谢综合征与成人心血管疾病的相关性。使用了来自美国国家心肺血液研究所脂质研究诊所普林斯顿患病率研究（1973–1976）和普林斯顿随访研究（2000–2004）的数据。由于未在Lipid Research Clinics研究中测量腰围，因此将BMI用作儿童肥胖症的量度。通过参与者报告获得参与者及其父母的成人心血管疾病状况。逻辑分析用于预测成人心血管疾病。儿童代谢综合征，普林斯顿随访研究的年龄，性别，种族和父母的心血管疾病史是潜在的解释变量。脂质研究临床研究的年龄为6至19岁，普林斯顿随访研究的年龄为30至48岁。普林斯顿后续研究中的分析队列中有17例心血管疾病。小儿代谢综合征和随访评估时的年龄是心血管疾病的重要预测指标。小儿代谢综合症以及从儿童到成年的特定年龄BMI百分数的变化是成人代谢综合症的重要预测指标。对儿童进行代谢综合征的评估可以确定患成人心血管疾病风险增加的患者，从而有针对性地进行干预。
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