OBJECTIVES. Establishing pediatric reference intervals has always been challenging, with most ranges used in pediatric laboratories developed over many years. The clinical interpretation of gonadotropins is important in the context of ambiguous genitalia. The aim of this study was to develop reference intervals for luteinizing hormone and follicle-stimulating hormone in infants born between 24 and 29 weeks’ gestation.METHODS. Samples were collected at 0 to 43 days after birth from 82 premature infants born 30 weeks’ gestation for analysis of luteinizing hormone and follicle-stimulating hormone by automated immunochemiluminometric immunoassays.RESULTS. The 43 male infants demonstrated a range of luteinizing hormone levels from 0.1 to 13.4 IU/L and of follicle-stimulating hormone levels from 0.3 to 4.6 IU/L. The 39 female infants demonstrated a range of luteinizing hormone levels from 0.2 to 54.4 IU/L and of follicle-stimulating hormone levels from 1.2 to 167.0 IU/L. The ratio of luteinizing hormone/follicle-stimulating hormone levels differed with males, ranging from 0.3 to 9.4, and females, at 0.5.CONCLUSION. These data provide guidance for the interpretation of luteinizing hormone and follicle-stimulating hormone levels for the first 6 weeks of life in extremely premature infants born between 24 and 29 weeks’ gestation. The availability of age-appropriate reference intervals is essential for correct and timely interpretation of biochemical results to the clinician.
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机译：目标建立儿科参考间隔一直是一项挑战，因为多年来在儿科实验室中使用的大多数范围。在生殖器模棱两可的情况下，促性腺激素的临床解释很重要。这项研究的目的是为妊娠24至29周之间出生的婴儿制定黄体生成激素和促卵泡激素的参考间隔。在出生后0至43天时，从82个胎龄小于30周的早产儿中收集了样品，用于通过自动免疫化学发光免疫分析法分析黄体生成素和促卵泡激素。 43名男婴的促黄体激素水平范围从0.1到13.4 IU / L，促卵泡激素水平从0.3到4.6 IU / L。 39名女婴的促黄体激素水平范围从0.2到54.4 IU / L，促卵泡激素水平从1.2到167.0 IU / L。黄体生成素/促卵泡激素水平的比率在男性之间为0.3至9.4，女性在<0.5。结论。这些数据可为解释妊娠24至29周的极早产儿出生后前6周的黄体生成素和促卵泡激素水平提供指导。是否有适合年龄的参考间隔对于正确及时地向临床医生解释生化结果至关重要。
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