* Abbreviations: CI a?? : confidence interval GERD a?? : gastroesophageal reflux disease PPI a?? : proton pump inhibitor Gastroesophageal reflux disease (GERD) is the most common medical complaint in pregnancy, manifesting as heartburn and regurgitation. GERD occurs in 25% to 80% of women, with the prevalence varying according to definition and nationality.1a??3 Initial management involves lifestyle changes and/or antacids, followed by a standard treatment of acid-suppressive medications such as histamine-2 receptor antagonists and proton pump inhibitors (PPIs).1 Maternal use of PPIs in pregnancy has been shown to be safe in relation to birth defects, spontaneous abortions, and preterm delivery.4,5 However, there is a growing number of epidemiologic studies to suggest that maternal use of acid-suppressive medications in pregnancy is associated with an increased risk of asthma in the offspring. In the current edition of Pediatrics , Lai et al6 have published a meta-analysis of 8 such studies, concluding that there is a risk of children developing asthma with prenatal exposure to PPIs (odds ratio: 1.34; 95% confidence interval [CI]: 1.18a??1.52) and histamine-2 receptor antagonists (odds ratio: 1.57; 95% CI: 1.46a??1.69). To explore this further, it is interesting to first ask the following question: why study prenatal acid-suppressive medication exposure and asthma in offspring? There are several a?| Address correspondence to Bronwyn K. Brew, PhD, Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Nobels vag 12a, Stockholm 17177, Sweden. E-mail: bronwyn.haasdyk.brew{at}ki.se
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机译：*缩写：CI a ?? ：置信区间GERD a？ ：胃食管反流病PPI a ?? ：质子泵抑制剂胃食管反流病（GERD）是妊娠中最常见的医学疾病，表现为烧心和反流。 GERD发生在25％至80％的女性中，其流行率根据定义和国籍而有所不同。1a?? 3初始管理涉及生活方式的改变和/或抗酸剂，然后是标准的抗酸药物（如组胺2）的治疗。受体拮抗剂和质子泵抑制剂（PPIs）。1已证明在妊娠中母亲使用PPI与出生缺陷，自然流产和早产有关是安全的。4,5然而，越来越多的流行病学研究提示孕妇在怀孕期间使用抑酸药物会增加后代患哮喘的风险。在最新版的《儿科》中，Lai等[6]进行了荟萃分析，对8项此类研究进行了荟萃分析，得出结论认为，儿童在产前暴露于PPI时有患哮喘的风险（比值：1.34; 95％置信区间[CI]： 1.18a 12 -1.52）和组胺2受体拮抗剂（几率：1.57; 95％CI：1.46a-1.69）。为了进一步探讨这一问题，有趣的是首先要问以下问题：为什么要研究产前酸抑制药物的暴露和后代哮喘？有几个？地址为瑞典斯德哥尔摩诺贝尔斯vag 12a的Karolinska研究所医学流行病学和生物统计学系Bronwyn K. Brew博士的来信。电子邮件：bronwyn.haasdyk.brew {at} ki.se
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