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>Expression of Very Late Antigen-4 and Lymphocyte Function-Associated Antigen-1 on Peripheral Blood Lymphocytes from Patients with Graves Disease
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Expression of Very Late Antigen-4 and Lymphocyte Function-Associated Antigen-1 on Peripheral Blood Lymphocytes from Patients with Graves Disease
The aim of the study was to estimate the expression of β1 integrin CD49d (very late antigen-4), β2 integrin CD11a (lymphocyte function-associated antigen 1 alpha), l-selectin (CD62L), and intercellular adhesion molecule-1 [ICAM-1 (CD54)] on peripheral blood mononuclear cells in patients with Graves disease (GD) (n = 45, mean age 15.9 ± 5.9 y), in patients with nontoxic nodular goiter (NTNG) (n = 25, mean age 15.2 ± 5.7 y), and in sex- and age-matched healthy control subjects (n = 25, mean age 15.9 ± 2.4 y). The expression of the lymphocyte adhesion molecules was analyzed by the three-color flow cytometry. Decreased percentages of CD49d+ and CD11a+ lymphocytes were observed in untreated Graves' patients in comparison to healthy controls (p p p p + and CD54+ antigen expression on peripheral blood lymphocytes revealed increased percentages of l-selectin- and ICAM-1-positive cells in patients with GD (p p + lymphocytes (r = 0.47, p + lymphocytes (r = ?0.39, p Abbreviations: PE, phycoerythrin; PerCP, peridinin chlorophyll protein; FT3, free triiodothyronine; fT4, free thyroxine; TRAb, antibodies against receptor for TSH; TPO-Ab, antithyroid peroxidase antibodies; TG-Ab, antithyroglobulin antibodies; VLA, very late antigen; LFA-1, lymphocyte function-associated antigen-1; ICAM-1, intercellular adhesion molecule-1; VCAM-1, vascular cell adhesion molecule-1; AITD, autoimmune thyroid disease; GD, Graves disease; NTNG, non-toxic nodular goiter
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