Most patients with primary gout show normal uric acid (UA) production rates and a relative underexcretion of UA. To examine if the renal dysfunction for UA excretion in primary gout also affects the excretion of UA precursors, we compared the plasma concentrations and 24 hour urinary excretion of Hx and X in 10 normal suojects, 15 patients with primary gout and UA underexcretion and 10 patients with diverse enzyme deficiencies known to overproduce UA. All subjects showed a creatinine clearance above 80 ml/min/1.73 m2. Results (mean±SEM) were as followsUrinary UA excretion was correlated with Hx and X excretion (r=0.857; P<0.01 and r=0.927; P<0.01, respectively). A significant direct relationship was found between the renal clearances of UA, Hx and X. These results indicate that patients with gout who underexcrete UA are also underexcretors for Hx and X. The renal impairment for UA excretion in primary gout appears to be more extensive than previously recognized.
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机译：大多数患有痛风的患者表现出正常的尿酸（UA）产生率和相对较低的UA排泄。为了检查原发痛风中肾功能失调是否也影响UA前体的排泄，我们比较了10例正常人，15例原发痛风和UA排泄不足的患者以及10例患者血浆中Hx和X的浓度以及24小时尿液排泄具有已知会导致UA过量生产的多种酶缺陷。所有受试者均显示肌酐清除率高于80 ml / min / 1.73 m2。结果（平均值±SEM）如下：尿UA排泄与Hx和X排泄相关（r = 0.857; P <0.01和r = 0.927; P <0.01）。发现UA，Hx和X的肾脏清除率之间存在显着的直接关系。这些结果表明，痛风患者UA排泄不足，同时也是Hx和X排泄不足。原发性痛风中UA排泄的肾脏损害似乎比UA排泄更为广泛。先前认可的。
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