pWe have found that purified human peripheral-blood granulocytes express constitutively significant levels of proto-oncogenes c-jun, jun B and jun D mRNA. Upon functional activation of granulocytes by 4 beta-phorbol 12-myristate 13-acetate (PMA), the levels of c-jun, jun B and jun D transcripts were increased. The three jun genes showed a similar time course in their induction by PMA, maximal mRNA levels being reached after 60 min of induction. These results suggest that expression of c-jun, jun B and jun D genes might be involved in terminal granulocyte differentiation or in regulating granulocyte functionality./p
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机译：>我们发现，纯化的人外周血粒细胞表达组成型显着水平的原癌基因c-jun，jun B和jun D mRNA。通过4β-佛波醇12-肉豆蔻酸酯13-乙酸酯（PMA）激活粒细胞后，c-jun，jun B和jun D转录物的水平增加。三个jun基因在PMA诱导中显示出相似的时间过程，诱导60分钟后达到最大mRNA水平。这些结果提示c-jun，jun B和jun D基因的表达可能参与了粒细胞的终末分化或调节粒细胞的功能。
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