pGBS (Group B iStreptococcus/i) requires capsular Sia (sialic acid) for virulence and partially modifies this sugar by O-acetylation. In the present paper we describe serotype-specific patterns of GBS Sia O-acetylation that can be manipulated by genetic and biochemical means. iIn vitro/i and iin vivo/i assays demonstrate that this subtle modification attenuates GBS Sia-mediated neutrophil suppression and animal virulence./p
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机译：> GBS（B组链球菌）需要荚膜Sia（唾液酸）才能具有毒性，并通过O-乙酰化部分修饰该糖。在本文中，我们描述了可以通过遗传和生化手段操纵的GBS Sia O-乙酰化的血清型特异性模式。 体外和体内分析表明，这种微妙的修饰减弱了GBS Sia介导的中性粒细胞抑制和动物毒力。
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