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首页> 外文期刊>The journal of immunology >A Human CTL Recognizes a Caspase-8-Derived Peptide on Autologous HLA-B*3503 Molecules and Two Unrelated Peptides on Allogeneic HLA-B*3501 Molecules
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A Human CTL Recognizes a Caspase-8-Derived Peptide on Autologous HLA-B*3503 Molecules and Two Unrelated Peptides on Allogeneic HLA-B*3501 Molecules

机译：人类CTL识别自体HLA-B * 3503分子上的caspase-8衍生肽和同种异体HLA-B * 3501分子上的两个无关肽

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摘要

A CTL clone that recognizes autologous tumor cells was previously isolated from the blood of a head-and-neck cancer patient. The Ag was identified as peptide FPSDSWCYF presented by autologous HLA-B*3503 molecules. This peptide was encoded by a mutated CASP-8 gene, which is implicated in the triggering of apoptosis. Here, we show that this CTL clone, which expresses a single TCR, also recognizes two unrelated peptides on allogeneic HLA-B*3501 molecules. One peptide, HIPDVITY, is encoded by squalene synthase, and the other one, QFADVIVLF, is encoded by 2-hydroxyphytanoyl-CoA lyase. Both genes are expressed ubiquitously. These antigenic peptides are processed and presented by HLA-B*3501 cells. The two HLA-B35 alleles are closely related. Our results might reinforce the notion that the recognition of allogeneic HLA molecules depends on the presence in their groove of a limited number of peptides processed from ubiquitous proteins.
机译：先前从头颈癌患者的血液中分离出识别自体肿瘤细胞的CTL克隆。 Ag被鉴定为自体HLA-B * 3503分子呈递的肽FPSDSWCYF。该肽由突变的CASP-8基因编码，其与细胞凋亡的触发有关。在这里，我们显示该CTL克隆，表达单个TCR，还识别同种异体HLA-B * 3501分子上的两个不相关的肽。一种肽HIPDVITY由角鲨烯合酶编码，另一种QFADVIVLF由2-羟基植烷酰基-CoA裂解酶编码。这两个基因无处不在。这些抗原肽由HLA-B * 3501细胞加工并呈递。这两个HLA-B35等位基因密切相关。我们的结果可能会强化这样的观念，即同种异源HLA分子的识别取决于其凹槽中是否存在从泛在蛋白中加工而来的有限数量的肽。

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