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首页> 外文期刊>The journal of immunology >CD1 Antigen Presentation by Human Dendritic Cells as a Target for Herpes Simplex Virus Immune Evasion
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CD1 Antigen Presentation by Human Dendritic Cells as a Target for Herpes Simplex Virus Immune Evasion

机译：人类树突状细胞的CD1抗原呈递作为单纯疱疹病毒免疫逃逸的目标。

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In contrast to MHC molecules, which present peptides, the CD1 molecules have been discovered to present lipid Ags to T cells. CD1-restricted T lymphocytes have been recently associated with resistance to virus infection. The mechanisms underlying activation of CD1-restricted T cells in the course of virus infection are not defined. In this study, we wanted to investigate the interaction of HSV with the antiviral CD1 Ag presentation system in human dendritic cells (DC). In response to low titers of HSV, the surface expression of CD1b and CD1d on human DC was up-regulated. These phenotypic changes enhanced the capacity of infected DC to stimulate proliferation of CD1-restricted T lymphocytes. High titers of HSV, however, lead to strong down-regulation of all surface CD1 molecules. This modulation of surface expression was associated with intracellular accumulation, colocalization with viral proteins, and disruption of the CD1 recycling machinery. Finally, even at low titers HSV interfered with the capacity of infected DC to stimulate the release of important cytokines by CD1d-restricted NKT cells. Thus, we demonstrate both the existence of a CD1 pathway allowing human DC to react to viral infection, as well as its blockage by a human herpesvirus.
机译：与呈递肽的MHC分子相反，已发现CD1分子向T细胞呈递脂质Ags。最近，CD1限制性T淋巴细胞与抗病毒感染有关。在病毒感染过程中激活CD1限制性T细胞的潜在机制尚未明确。在这项研究中，我们想调查人类树突状细胞（DC）中HSV与抗病毒CD1 Ag呈递系统的相互作用。响应低滴度的HSV，CD1b和CD1d在人DC上的表面表达被上调。这些表型变化增强了感染的DC刺激CD1限制性T淋巴细胞增殖的能力。但是，高滴度的HSV会导致所有表面CD1分子强烈下调。表面表达的这种调节与细胞内积累，病毒蛋白的共定位和CD1回收机制的破坏有关。最后，即使在低滴度下，HSV也会干扰受感染DC刺激CD1d限制的NKT细胞释放重要细胞因子的能力。因此，我们证明了允许人类DC对病毒感染起反应的CD1途径的存在，以及其被人类疱疹病毒的阻断。

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