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首页> 外文期刊>The journal of immunology >Intact Bacteria Inhibit the Induction of Humoral Immune Responses to Bacterial-Derived and Heterologous Soluble T Cell-Dependent Antigens
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Intact Bacteria Inhibit the Induction of Humoral Immune Responses to Bacterial-Derived and Heterologous Soluble T Cell-Dependent Antigens

机译：完整细菌抑制对细菌衍生和异源可溶性T细胞依赖性抗原的体液免疫反应的诱导。

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摘要

During infections with extracellular bacteria, such as Streptococcus pneumoniae (Pn), the immune system likely encounters bacterial components in soluble form, as well as those associated with the intact bacterium. The potential cross-regulatory effects on humoral immunity in response to these two forms of Ag are unknown. We thus investigated the immunologic consequences of coimmunization with intact Pn and soluble conjugates of Pn-derived proteins and polysaccharides (PS) as a model. Coimmunization of mice with Pn and conjugate resulted in marked inhibition of conjugate-induced PS-specific memory, as well as primary and memory anti-protein Ig responses. Inhibition occurred with unencapsulated Pn, encapsulated Pn expressing different capsular types of PS than that present in the conjugate, and with conjugate containing protein not expressed by Pn, but not with 1-μm latex beads in adjuvant. Inhibition was long-lasting and occurred only during the early phase of the immune response, but it was not associated with tolerance. Pn inhibited the trafficking of conjugate from the splenic marginal zone to the B cell follicle and T cell area, strongly suggesting a potential mechanism for inhibition. These data suggest that during infection, bacterial-associated Ags are the preferential immunogen for antibacterial Ig responses.
机译：在感染诸如肺炎链球菌（Pn）的细胞外细菌时，免疫系统可能会遇到可溶形式的细菌成分以及与完整细菌相关的成分。响应这两种形式的银，对体液免疫的潜在交叉调节作用尚不清楚。因此，我们研究了与完整Pn和Pn衍生蛋白和多糖（PS）的可溶性结合物共免疫的免疫学后果。用Pn和结合物对小鼠进行共免疫可显着抑制结合物诱导的PS特异性记忆以及原发性和记忆性抗蛋白Ig反应。抑制作用发生在未包封的Pn，表达与缀合物中存在的PS荚膜类型不同的PS的包囊Pn以及含有未由Pn表达的蛋白的缀合物，但在辅助剂中未包含1-μm乳胶珠的情况下。抑制作用是持久的，仅在免疫反应的早期发生，但与耐受性无关。 Pn抑制了结合物从脾边缘区域向B细胞滤泡和T细胞区域的运输，这强烈暗示了抑制的潜在机制。这些数据表明，在感染过程中，细菌相关抗原是抗菌Ig反应的优先免疫原。

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