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首页> 外文期刊>The Journal of Experomental Medicine >AUTORADIOGRAPHIC ANALYSIS OF LYMPHOPOIESIS AND LYMPHOCYTE MIGRATION IN MICE BEARING MULTIPLE THYMUS GRAFTS
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AUTORADIOGRAPHIC ANALYSIS OF LYMPHOPOIESIS AND LYMPHOCYTE MIGRATION IN MICE BEARING MULTIPLE THYMUS GRAFTS

机译：携带多个胸腺移植物的小鼠淋巴组织和淋巴细胞迁移的放射自显影分析

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Lymphopoiesis was studied in 3-month-old normal C57Bl mice and in 3-month-old C57Bl mice carrying from 12 to 48 C57Bl thymus grafts using tritiated thymidine labeling.Thymus graft lymphopoiesis was found to be identical with that of normal thymus tissue and the presence of thymus grafts was found to have no influence on host thymus lymphopoiesis.No evidence was found that the massive amounts of thymus graft tissue in the mice affected any parameter of host lymph node lymphopoiesis nor was any evidence detected for the migration of thymic lymphocytes from these massive deposits of thymus graft tissue either to host lymph nodes and blood or to other organs in the host animal.It is concluded that the majority of small lymphocytes produced in the thymus and thymus graft tissue do not migrate from these tissues but die locally at the end of their intrathymic life span of 3 to 4 days.
机译：在3个月大的正常C57B1小鼠和携带12至48个C57B1胸腺移植物的3个月大的C57B1小鼠中使用using标记的胸腺嘧啶核苷对淋巴细胞进行了研究。发现胸腺移植物的淋巴细胞生成与正常胸腺组织相同发现胸腺移植物的存在对宿主胸腺淋巴细胞没有影响。没有证据表明小鼠中大量的胸腺移植组织会影响宿主淋巴结淋巴细胞的任何参数，也没有发现任何证据证明胸腺淋巴细胞从这些大量的胸腺移植组织沉积物既可以宿主淋巴结和血液，也可以扩散到宿主动物的其他器官。结论是，胸腺和胸腺移植组织中产生的大多数小淋巴细胞不会从这些组织中迁移出来，而是在局部死亡。他们的胸腺内寿命结束3到4天。

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