• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>The Journal of Experomental Medicine >Spleen cells from adult mice given total lymphoid irradiation or from newborn mice have similar regulatory effects in the mixed leukocyte reaction. I. Generation of antigen-specific suppressor cells in the mixed leukocyte reaction after the addition of spleen cells from adult mice given total lymphoid irradiation.
【24h】

Spleen cells from adult mice given total lymphoid irradiation or from newborn mice have similar regulatory effects in the mixed leukocyte reaction. I. Generation of antigen-specific suppressor cells in the mixed leukocyte reaction after the addition of spleen cells from adult mice given total lymphoid irradiation.

机译：接受全淋巴细胞照射的成年小鼠或新生小鼠的脾细胞在混合白细胞反应中具有类似的调节作用。 I.在给了全淋巴照射的成年小鼠中添加脾细胞后，在混合白细胞反应中产生了抗原特异性抑制细胞。

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

We added spleen cells from adult BALB/c mice treated with total lymphoid irradiation (TLI) to the mixed leukocyte reaction (MLR) using a variety of responder and stimulator cells. The spleen cells nonspecifically suppressed the uptake of [3H]-thymidine and the generation of cytolytic cells regardless of the responder-stimulator combination used. We also examined the effect of the spleen cells on the generation of antigen-nonspecific and antigen-specific suppressor cells in the MLR. The experimental results suggest that the spleen cells from TLI-treated mice inhibit the generation of nonspecific suppressor cells, but do not inhibit the generation of antigen-specific suppressor cells. Thus, alloantigenic stimulation of normal responder cells in vitro in the presence of spleen cells from TLI-treated mice generates large numbers of antigen-specific suppressor cells, but few cytolytic cells or nonspecific suppressor cells. Similar nonspecific inhibition of the MLR was observed with neonatal spleen cells. This in vitro system provides a regulatory model for the induction and maintenance of tolerance in vivo, in which adult mice given TLI or neonatal mice accept allogeneic bone marrow transplants without graft-vs.-host disease.
机译：我们使用各种响应细胞和刺激细胞，将经总淋巴照射（TLI）处理的成年BALB / c小鼠的脾细胞添加到混合白细胞反应（MLR）中。脾脏细胞非特异性地抑制[3 H]-胸腺嘧啶核苷的摄取和溶细胞的产生，而与所使用的应答剂-刺激剂组合无关。我们还检查了脾细胞对MLR中抗原非特异性和抗原特异性抑制细胞产生的影响。实验结果表明，经TLI处理的小鼠的脾细胞抑制非特异性抑制细胞的生成，但不抑制抗原特异性抑制细胞的生成。因此，在存在来自TLI处理的小鼠的脾细胞的情况下，在体外对正常应答细胞的同种异体抗原刺激会产生大量的抗原特异性抑制细胞，但很少有溶细胞性细胞或非特异性抑制细胞。用新生儿脾细胞观察到类似的对MLR的非特异性抑制。该体外系统为体内耐受性的诱导和维持提供了调节模型，其中给予TLI的成年小鼠或新生小鼠接受同种异体骨髓移植而无移植物抗宿主病。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号