Human sperm carbohydrate antigens defined by an antisperm human monoclonal antibody derived from an infertile woman bearing antisperm antibodies in her serum.

Y Tsuji; H Clausen; E Nudelman; T Kaizu; S Hakomori; S Isojima

首页> 外文期刊>The Journal of Experomental Medicine >Human sperm carbohydrate antigens defined by an antisperm human monoclonal antibody derived from an infertile woman bearing antisperm antibodies in her serum.

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Human sperm carbohydrate antigens defined by an antisperm human monoclonal antibody derived from an infertile woman bearing antisperm antibodies in her serum.

机译：人精子碳水化合物抗原由抗精子人单克隆抗体定义，该抗体来自不育妇女，其血清中带有抗精子抗体。

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The epitope structure of the human sperm antigen reacting with antibodies present in sera of infertile women has been studied using mAb H6-3C4, which produces immobilization of human sperm in the presence of complement. Another antibody, NUH2, which also induces human sperm immobilization, was used to substantiate the presence of a receptor on sperm involved in susceptibility to immobilization. Both antibodies defined type 2 chain polylactosamine structure. H6-3C4 is directed to internally located repetitive N-acetyllactosamine, i.e., sialyl-i, i, or fucosyl-i. NUH2 defines binary alpha 2---|-3 sialyl type 2 chain, i.e., sialyl-I. Thus, the presence of antibodies in the sera of infertile women directed to sperm lactosaminoglycan or lactosaminolipid could be the basis for infertility in these cases.

机译：已使用mAb H6-3C4研究了可与不育女性血清中存在的抗体发生反应的人类精子抗原的表位结构，该抗体在补体存在下可固定人类精子。另一种抗体NUH2也可诱导人类精子的固定化，用于证实精子上受体与固定化敏感性有关的受体的存在。两种抗体均定义了2型链聚乳糖胺结构。 H6-3C4涉及内部重复的N-乙酰基乳糖胺，即唾液酸-i，i或岩藻糖基-i。 NUH2定义二元alpha 2 --- | -3唾液酸2型链，即唾液酸I。因此，在不育妇女的血清中针对精子乳糖胺聚糖或乳糖胺脂的抗体的存在可能是这些情况下不孕的基础。

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《The Journal of Experomental Medicine》 |1988年第1期|共14页
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Y Tsuji; H Clausen; E Nudelman; T Kaizu; S Hakomori; S Isojima;
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中图分类医用一般科学;
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1. Identification of evolutionary conserved mouse sperm surface antigens by human antisperm antibodies (ASA) from infertile patients. [J] . Paradowska A, Bohring C, Krause E, AJRI: American Journal of Reproductive Immunology . 2006,第5期

机译：通过不育患者的人类抗精子抗体（ASA）鉴定进化保守的小鼠精子表面抗原。
2. Characterization of human sperm antigens reacting with anti-sperm antibodies from an infertile female patient's serum. [J] . Feng HL, Han YB, Sparks AE, Journal of Andrology . 2008,第4期

机译：人类精子抗原与不育女性患者血清中抗精子抗体反应的特征。
3. Characterization of human sperm antigens reacting with anti-sperm antibodies from an infertile female patient's serum. [J] . Feng HL, Han YB, Sparks AE, Journal of Andrology . 2008,第4期

机译：人类精子抗原与不育女性患者血清中抗精子抗体反应的特征。
4. A Comparison of Pregnancy Rates in Female Partners of Males with Sperm Laden with Antisperm Antibodies Following Intrauterine Insemination (IUI) with Sperm Treated with Chymotrypsin Galactose vs. In Vitro Fertilization (IVF) with Intracytoplasmic Sperm Injection (ICSI) [C] . A. Bollendorf, J.H. Check, C. Wilson International Congress of Andrology . 2009

机译：用宫内生精（IUI）与宫内节制物（IUI）用胰蛋白酶蛋白酶蛋白酶蛋白酶术（IVF）对宫内节制物（IUI）患有抗血糖抗体的妊娠抗体与抗血清抗体的妊娠率比较。（ICSI）
5. Immunoglobulin variable region sequences of two human monoclonal antibodies directed to an onco-developmental carbohydrate antigen, lactotetraosylceramide(LcOse[4]Cer) [D] . Yago, Kazuhiro 1994

机译：两种针对人肿瘤发育碳水化合物抗原乳四糖神经酰胺（LcOse [4] Cer）的免疫球蛋白可变区序列
6. Human sperm carbohydrate antigens defined by an antisperm human monoclonal antibody derived from an infertile woman bearing antisperm antibodies in her serum [O] . 1988

机译：人类精子碳水化合物抗原是由抗精子人类单克隆抗体定义的该抗体来自不育妇女的血清中带有抗精子抗体
7. Human sperm carbohydrate antigens defined by an antisperm human monoclonal antibody derived from an infertile woman bearing antisperm antibodies in her serum [O] . 1988

机译：人类精子碳水化合物抗原是由抗精子人类单克隆抗体定义的，该抗体来自不育妇女的血清中带有抗精子抗体

Human sperm carbohydrate antigens defined by an antisperm human monoclonal antibody derived from an infertile woman bearing antisperm antibodies in her serum.

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