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首页> 外文期刊>The Journal of Experomental Medicine >Interleukin 1 enhances growth factor-dependent proliferation of the clonogenic cells in acute myeloblastic leukemia and of normal human primitive hemopoietic precursors.
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Interleukin 1 enhances growth factor-dependent proliferation of the clonogenic cells in acute myeloblastic leukemia and of normal human primitive hemopoietic precursors.

机译：白介素1增强急性粒细胞性白血病和正常人原始造血前体中克隆细胞的生长因子依赖性增殖。

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IL-1 is released by activated monocytes and is thought to be a key mediator of the host immune response. The availability of the purified and, more recently, recombinant IL-1 has allowed the characterization of other biological properties of this molecule. Thus, IL-1 is thought to have the same properties as hemopoietic 1, a growth factor that has been shown to act on primitive murine hemopoietic cells. Here we report that rIL-1 acts synergistically with granulocyte/macrophage CSF (GM-CSF) or granulocyte CSF in the stimulation of clonogenic cells from many patients with acute myeloblastic leukemia (AML). Although IL-1 by itself has no effect on AML blasts, it can support colony formation under conditions where there is detectable production of endogenous GM-CSF. IL-1 also promotes the growth of multipotential progenitors from normal human bone marrow cells in the presence of GM-CSF. These observations support the hypothesis that in the hemopoietic system, IL-1 has a selective effect on primitive precursors.
机译：IL-1由活化的单核细胞释放，并被认为是宿主免疫反应的关键介体。纯化的和最近重组的IL-1的可用性已经可以表征该分子的其他生物学特性。因此，认为IL-1具有与造血细胞1相同的特性，造血细胞1已被证明可作用于原始鼠造血细胞。在这里，我们报道rIL-1与粒细胞/巨噬细胞CSF（GM-CSF）或粒细胞CSF协同作用，可刺激许多急性粒细胞性白血病（AML）患者的克隆细胞。尽管IL-1本身对AML胚细胞没有影响，但它可以在可检测到内源性GM-CSF产生的条件下支持菌落形成。在存在GM-CSF的情况下，IL-1还促进正常人骨髓细胞中多能祖细胞的生长。这些观察结果支持以下假设：在造血系统中，IL-1对原始前体具有选择性作用。

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