Pregnancy-associated Malaria and the Prospects for Syndrome-specific Antimalaria Vaccines

Joseph D. Smith; Kirk W. Deitsch

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Pregnancy-associated Malaria and the Prospects for Syndrome-specific Antimalaria Vaccines

机译：妊娠相关疟疾和综合症特异性抗疟疾疫苗的前景。

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Aided by the Plasmodium falciparum genome project, recent discoveries regarding the molecular basis of malaria pathogenesis have led to a better understanding of the interactions between host and parasite. Although vaccines that prevent infection by malaria parasites remain only hopes for the future, there are now more immediate prospects for vaccines that protect against specific disease syndromes. Here, we discuss the latest advances in the development of a vaccine that specifically targets pregnancy-associated malaria (PAM).

机译：在恶性疟原虫基因组计划的帮助下，有关疟疾发病机理的分子基础的最新发现使人们对宿主与寄生虫之间的相互作用有了更好的了解。尽管预防疟疾寄生虫感染的疫苗仍然只是未来的希望，但如今，针对特定疾病综合症的疫苗具有更广阔的前景。在这里，我们讨论专门针对妊娠相关疟疾（PAM）的疫苗开发的最新进展。

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《The Journal of Experomental Medicine》 |2004年第9期|共5页
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Joseph D. Smith; Kirk W. Deitsch;
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中图分类医用一般科学;
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1. Prospects and Pitfalls of Pregnancy-Associated Malaria Vaccination Based on the Natural Immune Response toPlasmodium falciparumVAR2CSA-Expressing Parasites [J] . Elizabeth G.Kane, Andrew W.Taylor-Robinson Malaria research and treatment . 2011,第4期

机译：基于对恶性疟原虫VAR2CSA表达寄生虫的天然免疫反应的妊娠相关疟疾疫苗的前景和陷阱。
2. First-in-human, Randomized, Double-blind Clinical Trial of Differentially Adjuvanted PAMVAC, A Vaccine Candidate to Prevent Pregnancy-associated Malaria [J] . Mordmueller Benjamin, Sulyok Mihaly, Egger-Adam Diane, Clinical infectious diseases . 2019,第9期

机译：差异辅助PAMVAC的第一单人，随机，双盲临床试验，疫苗候选者，以防止妊娠相关的疟疾
3. Evidence for Globally Shared, Cross-Reacting Polymorphic Epitopes in the Pregnancy-Associated Malaria Vaccine Candidate VAR2CSA [J] . Marion Avril, Bridget R. Kulasekara, Severin O. Gose, Infection and immunity . 2008,第4期

机译：妊娠相关疟疾疫苗候选VAR2CSA中全球共享的，交叉反应的多态性表位的证据
4. A CLINICALLY VALIDATED DROSOPHILA S2 BASED VACCINE PLATFORM FOR PRODUCTION OF MALARIA VACCINES [C] . Thomas Jorgensen, Max Soegaard, Ali Salanti, Conference on vaccine technology VI . 2018

机译：用于生产疟疾疫苗的临床验证的基于果蝇S2的疫苗平台
5. Interaction of PfEMP1 with the human immune system and the prospect of PfEMP1-based vaccine for malaria [D] . Magale, Hussein 2016

机译：PfEMP1与人类免疫系统的相互作用以及基于PfEMP1的疟疾疫苗的前景
6. Pregnancy-associated Malaria and the Prospects for Syndrome-specific Antimalaria Vaccines [O] . Joseph D. Smith, Kirk W. Deitsch 2004

机译：妊娠相关疟疾和综合症特异性抗疟疾疫苗的前景。
7. Pregnancy-associated Malaria and the Prospects for Syndrome-specific Antimalaria Vaccines [O] . Smith, Joseph D., Deitsch, Kirk W. 2004

机译：妊娠相关疟疾和综合症特异性抗疟疾疫苗的前景。
8. Prospects and Strategies for Development of DNA Vaccines Against Malaria [R] . Hedstrom, R. C., Sedegah, M., Hoffman, S. L. 1994

机译：开发针对疟疾的DNa疫苗的前景和策略

Pregnancy-associated Malaria and the Prospects for Syndrome-specific Antimalaria Vaccines

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