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首页> 外文期刊>Hypertension: An Official Journal of the American Heart Association >Red-cell sodium-lithium countertransport and fractional excretion of lithium in normal and hypertensive humans.
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Red-cell sodium-lithium countertransport and fractional excretion of lithium in normal and hypertensive humans.

机译：正常人和高血压人的红细胞钠锂逆向转运和锂的部分排泄。

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摘要

To examine the relations between erythrocyte sodium-lithium countertransport and renal proximal tubular sodium handling, we measured countertransport, and then subjected 30 normal and 32 hypertensive subjects, both white and black, to provocative maneuvers of volume expansion and contraction. The fractional excretions of sodium and lithium were measured simultaneously. In agreement with previous studies, we found that countertransport in erythrocytes was elevated in hypertensive patients compared with normal subjects. We also observed that whites have a higher level of countertransport than blacks. In the basal state, we found that fractional sodium excretion of hypertensive patients was no different than in normal subjects, whereas the fractional lithium excretion of hypertensive persons was increased compared with normotensive values. Volume expansion with 2 1 0.9% saline administered intravenously during a 4-hour period provoked an exaggerated natriuresis and a greater increase in fractional lithium clearance in hypertensive patients compared with the control group. With volume expansion and contraction, fractional lithium clearance and countertransport were directly correlated. Our data suggest that hypertensive persons do not have increased proximal tubular sodium reabsorption compared with normal subjects. Further, the exaggerated natriuresis of hypertension is, in part, the result of increased distal solute delivery. The fact that our hypertensive patients were older may partially explain the discrepancies between this report and previous observations.
机译：为了检查红细胞钠-锂逆向转运与肾近端肾小管钠处理之间的关系，我们测量了逆向转运，然后对30名正常人和32名高血压受试者（无论是白人还是黑人）进行了体积膨胀和收缩的刺激性操作。同时测量钠和锂的排泄分数。与之前的研究一致，我们发现与正常受试者相比，高血压患者的红细胞逆转运增加。我们还观察到，白人的反转运水平高于黑人。在基础状态下，我们发现高血压患者的钠排泄分数与正常受试者无差异，而高血压患者的锂排泄分数与血压正常值相比有所增加。与对照组相比，在4小时内通过静脉内施用2 1 0.9％的盐水进行体积扩张，引起了高血压患者的钠尿过多和锂清除率的增加。随着体积的膨胀和收缩，分数锂清除率和逆向运输直接相关。我们的数据表明，与正常人相比，高血压患者近端肾小管钠盐重吸收没有增加。此外，高血压的尿钠过多，部分原因是远端溶质释放增加的结果。我们的高血压患者年龄较大，这一事实可能部分解释了本报告与先前观察结果之间的差异。

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