Evidence for neurotransmitter plasticity in vivo: Developmental changes in properties of cholinergic sympathetic neurons☆

Story C. Landis; Dennis Keefe

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Evidence for neurotransmitter plasticity in vivo: Developmental changes in properties of cholinergic sympathetic neurons☆

机译：体内神经递质可塑性的证据：胆碱能交感神经元特性的发育变化☆

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Wehaveexaminedthecholinergicsympatheticinnervationofsweatglandsinfootpadsofadultanddevelopingrats.Acetylcholinesterasestainingrevealsaplexusofheavilystainedfibersinthesweatglandsofadultrats.Reactionproductappearsamongandaroundbundlesofaxonsthatlieataconsiderabledistancefromthecellsofthesecretorytubule.Eachbundlecontains8a€“12axonsthatpossessnumerousvaricositiesandcontainsmallclearandlargedensecorevesicles.Theglandsofthehindpawsandtheirinnervationdevelopduringthefirstthreeweeksafterbirth.Catecholamine-containingaxonswereassociatedwiththeformingglands.At7and10days,intenselyfluorescentfiberssurroundedthetubules,andalloftheaxonprofilesassociatedwiththeglandscontainedsmallgranularvesicles(SGV)afterpermanganatefixationtorevealvesicularstoresofnorepinephrine.At14daysthesweatglandplexuswaslessintenselyfluorescentthanatearlieragesandrelativelyfewSGVwerepresent.By21days,noendogenouscatecholaminefluorescenceandnoSGVweredetectable.However,followingexposuretoexogenouscatecholamine,fluorescentfiberswerepresentinthesweatglandsofmatureratsandtheycorrespondedinpositionanddensitytotheplexuslocalizedwithacetylcholinesterasestaining.Catecholamineuptakewasblockedbyincubationinthecoldandbydesmethylimipramineandwasnotobservedincholinergicparasympatheticfibersintheirisorsalivaryglands.Afterintraperitonealadministrationof5-hydroxydopamineandpermanganatefixation,alltheaxonsinthesweatglandscontainedafewSGV.Thus,thedevelopingsweatglandsappeartobeinnervatedbynoradrenergicaxonsthatlosetheirstoresofendogenouscatecholaminesbutnottheircapacityforuptakeandstorageastheyelaborteanaxonalplexusinthematuringglands.Theseobservationssupportthehypothesisthatcholinergicsympatheticneuronsappeartoundergoatransitionfromnoradrenergictocholinergicfunctionduringdevelopmentinvivosimilartothatpreviouslydescribedincellculture.

机译：Wehaveexaminedthecholinergicsympatheticinnervationofsweatglandsinfootpadsofadultanddevelopingrats.Acetylcholinesterasestainingrevealsaplexusofheavilystainedfibersinthesweatglandsofadultrats.Reactionproductappearsamongandaroundbundlesofaxonsthatlieataconsiderabledistancefromthecellsofthesecretorytubule.Eachbundlecontains8a€“12axonsthatpossessnumerousvaricositiesandcontainsmallclearandlargedensecorevesicles.Theglandsofthehindpawsandtheirinnervationdevelopduringthefirstthreeweeksafterbirth.Catecholamine-containingaxonswereassociatedwiththeformingglands.At7and10days，intenselyfluorescentfiberssurroundedthetubules，andalloftheaxonprofilesassociatedwiththeglandscontainedsmallgranularvesicles（SGV）afterpermanganatefixationtorevealvesicularstoresofnorepinephrine.At14daysthesweatglandplexuswaslessintenselyfluorescentthanatearlieragesandrelativelyfewSGVwerepresent.By21days，noendogenouscatecholaminefluorescenceandnoSGVweredetectable.However，followingexposuretoexogenouscatecholamine，fluorescentfibers werepresentinthesweatglandsofmatureratsandtheycorrespondedinpositionanddensitytotheplexuslocalizedwithacetylcholinesterasestaining.Catecholamineuptakewasblockedbyincubationinthecoldandbydesmethylimipramineandwasnotobservedincholinergicparasympatheticfibersintheirisorsalivaryglands.Afterintraperitonealadministrationof5-hydroxydopamineandpermanganatefixation，alltheaxonsinthesweatglandscontainedafewSGV.Thus，thedevelopingsweatglandsappeartobeinnervatedbynoradrenergicaxonsthatlosetheirstoresofendogenouscatecholaminesbutnottheircapacityforuptakeandstorageastheyelaborteanaxonalplexusinthematuringglands.Theseobservationssupportthehypothesisthatcholinergicsympatheticneuronsappeartoundergoatransitionfromnoradrenergictocholinergicfunctionduringdevelopmentinvivosimilartothatpreviouslydescribedincellculture。

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《Developmental biology》 |1983年第2期|共页
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Story C. Landis; Dennis Keefe;
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1. Target-dependent specification of the neurotransmitter phenotype: cholinergic differentiation of sympathetic neurons is mediated in vivo by gp 130 signaling. [J] . Stanke M, Duong CV, Pape M, Development . 2006,第1期

机译：神经递质表型的靶标依赖性规格：交感神经元的胆碱能分化在体内通过gp 130信号传导介导。
2. Developmental changes in the neurotransmitter properties of dissociated sympathetic neurons: a cytochemical study of the effects of medium☆ [J] . Story C. Landis Developmental biology . 1980,第2期

机译：分离交感神经元神经递质特性的发育变化：介质作用的细胞化学研究☆
3. CNTF AND LIF ARE NOT REQUIRED FOR THE TARGET-DIRECTED ACQUISITION OF CHOLINERGIC AND PEPTIDERGIC PROPERTIES BY SYMPATHETIC NEURONS IN VIVO [J] . Francis NJ., Landis SC., Asmus SE. Developmental biology . 1997,第1期

机译：无需使用CNTF和LIF即可在体内由交感神经元直接定向地获得胆碱和肽的特性
4. Cholinergic effects on spectral properties of spike trains in rat cortical neurons [C] . Tateno, T., Jimbo, . 2004

机译：胆碱能对大鼠皮质神经元突波序列光谱特性的影响
5. Developmental mechanisms of sympathetic axon pathfinding, target selection and neurotransmitter expression. [D] . Guidry, Guy Louis. 1999

机译：交感神经轴突寻路，目标选择和神经递质表达的发展机制。
6. Chemical transmission between rat sympathetic neurons and cardiac myocytes developing in microcultures: evidence for cholinergic adrenergic and dual-function neurons. [O] . E J Furshpan, P R MacLeish, P H OLague, 1976

机译：大鼠交感神经元和微培养中发展的心肌细胞之间的化学传递：胆碱能肾上腺素能和双重功能神经元的证据。
7. Target-dependent specification of the neurotransmitter phenotype:cholinergic differentiation of sympathetic neurons is mediated in vivo by gp130 signaling [O] . 2006

机译：靶向神经递质表型的靶向规范：通过GP130信号传导在体内介导的交感神经元的胆碱能分化

Evidence for neurotransmitter plasticity in vivo: Developmental changes in properties of cholinergic sympathetic neurons☆

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