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首页> 外文期刊>Developmental biology >Analyses of fugu hoxa2 genes provide evidence for subfunctionalization of neural crest cell and rhombomere cis-regulatory modules during vertebrate evolution
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Analyses of fugu hoxa2 genes provide evidence for subfunctionalization of neural crest cell and rhombomere cis-regulatory modules during vertebrate evolution

机译：河豚hoxa2基因的分析为脊椎动物进化过程中神经c细胞和rhombomere顺式调节模块的亚功能提供了证据

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emHoxa2/emgeneisaprimaryplayerinregulationofcraniofacialprogramsofheaddevelopmentinvertebrates.HereweinvestigatetheevolutionofaemHoxa2/emneuralcrestenhanceridentifiedoriginallyinmousebycomparingandcontrastingthefuguemhoxa2a/emandemhoxa2b/emgeneswiththeirorthologousteleostandmammaliansequences.Usingsequenceanalysesincombinationwithtransgenicregulatoryassaysinzebrafishandmouseembryoswedemonstratesubfunctionalizationofregulatoryactivityforexpressioninhindbrainsegmentsandneuralcrestcellsbetweenthesetwofuguco-orthologs.emhoxa2a/emregulatorysequenceshaveretainedtheabilitytomediateexpressioninneuralcrestcellswhilethoseofemhoxa2b/emincludeemcis/em-elementsthatdirectexpressioninrhombomeres.Functionaldissectionoftheneuralcrestregulatorypotentialofthefuguemhoxa2a/emandemhoxa2b/emgenesidentifythepreviouslyunknownemcis/em-elementNC5,whichisimplicatedingeneratingthedifferentialactivityoftheenhancersfromthesegenes.TheNC5regionplaysasimilarroleintheabilityofthisenhancertomediatereporterexpressioninmice,suggestingitisaconservedcomponentinvolvedincontrolofneuralcrestexpressionofemHoxa2/eminvertebratecraniofacialdevelopment./p/div
机译：<在> HOXA2 的geneisaprimaryplayerinregulationofcraniofacialprogramsofheaddevelopmentinvertebrates.Hereweinvestigatetheevolutionofa <位置> HOXA2 的neuralcrestenhanceridentifiedoriginallyinmousebycomparingandcontrastingthefugu <位置> hoxa2a 和 hoxa2b 的geneswiththeirorthologousteleostandmammaliansequences.Usingsequenceanalysesincombinationwithtransgenicregulatoryassaysinzebrafishandmouseembryoswedemonstratesubfunctionalizationofregulatoryactivityforexpressioninhindbrainsegmentsandneuralcrestcellsbetweenthesetwofuguco-直系同源物。<在> hoxa2a 调控序列保持了在神经rest细胞中介导表达的能力，而 hoxa2b 包括顺-指导表达菱形的元素。 NC5元素，暗示着增强这些基因的增强程序的不同活性。NC5区域在此方面的作用相似小鼠介导的增强子表达，提示涉及保守成分控制 Hoxa2 无脊椎动物颅面发育的神经递质压迫。

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