Syncytia inhibition by immune lymphocytes: in vitro test for immunity to canine distemper.

S Krakowka; A L Wallace; A Koestner

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Syncytia inhibition by immune lymphocytes: in vitro test for immunity to canine distemper.

机译：免疫淋巴细胞对合胞体的抑制作用：体外测试犬瘟热的免疫力。

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A simple and rapid (24-h) assay for peripheral blood lymphocyte-associated immunity to canine distemper virus (CDV) is described. The test is based upon leukocyte-associated inhibition of CDV-induced syncytia formation in Vero cells. The technique quantitates the response morphologically, thereby eliminating the requirement for release of radiolabeled compounds. Positive results were determined from specific-pathogen-free and gnotobiotic dogs exposed to CDV via hyperimmunization, vaccination with a modified live virus vaccine, and after virulent virus infection. Preinoculation lymphocytes and lymphocytes from non-immune dogs did not inhibit CDV-induced syncytia formation. Maximum responses were observed 7 to 21 days after initial exposure and declined thereafter. The method can be used to further investigate the role of immune lymphocytes in the recovery from CDV infection.

机译：描述了一种针对犬瘟热病毒（CDV）的外周血淋巴细胞相关免疫的简单，快速（24小时）检测方法。该测试基于Vero细胞中CDV诱导的合胞体形成的白细胞相关抑制作用。该技术从形态上对反应进行定量，从而消除了释放放射性标记化合物的要求。从通过超免疫，改良活病毒疫苗接种以及在强毒病毒感染后暴露于CDV的无特定病原体和致生病的狗中确定了阳性结果。接种前的淋巴细胞和非免疫犬的淋巴细胞没有抑制CDV诱导的合胞体形成。初次接触后7至21天观察到最大反应，此后下降。该方法可用于进一步研究免疫淋巴细胞在CDV感染恢复中的作用。

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《Journal of Clinical Microbiology》 |1978年第3期|共6页
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S Krakowka; A L Wallace; A Koestner;
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中图分类医学微生物学（病原细菌学、病原微生物学）;
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1. Syncytia inhibition by immune lymphocytes: in vitro test for immunity to canine distemper. [J] . S Krakowka, A L Wallace, A Koestner Journal of Clinical Microbiology . 1978,第3期

机译：免疫淋巴细胞对合胞体的抑制作用：体外测试犬瘟热的免疫力。
2. Immunologically specific production of interferon in cultures of rabbit blood lymphocytes: association with in vitro tests for cell-mediated immunity. [J] . H Bartfeld, J Vilcek Infection and immunity . 1975,第5期

机译：兔血淋巴细胞培养物中干扰素的免疫学特异性产生：与细胞介导的免疫的体外测试相关。
3. Immunologically specific production of interferon in cultures of rabbit blood lymphocytes: association with in vitro tests for cell-mediated immunity. [J] . H Bartfeld, J Vilcek Infection and immunity . 1975,第5期

机译：兔血淋巴细胞培养物中干扰素的免疫学特异性产生：与细胞介导的免疫的体外测试相关。
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机译：人造人淋巴结：一种用于生成人抗体和体外免疫功能测试的装置
5. Effects of Prebiotic fibre Diets on Rat Mucosal Intestinal and Systemic Immunity and in Vitro Mechanistic Analysis of Anti-Inflammatory Effects of Lactobacillus Strains on Rat and Human Intestinal Epithelial Cells. [D] . McCarville, Justin. 2012

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6. Syncytia inhibition by immune lymphocytes: in vitro test for immunity to canine distemper. [O] . S Krakowka, A L Wallace, A Koestner 1978

机译：免疫淋巴细胞对合胞体的抑制作用：体外测试犬瘟热的免疫力。
7. Targeted in vitro and in vivo gene transfer into T Lymphocytes: potential of direct inhibition of allo-immune activation [O] . Khanna, Ashwani K, Mehra, Mandeep R 2006

机译：靶向体外和体内基因转移到T淋巴细胞：直接抑制同种免疫激活的潜力
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机译：神经递质通过来自美法仑固化的mOpC-315肿瘤携带者的脾细胞（化学疗法后的儿茶酚胺抑制肿瘤免疫）抑制对syngeneic mOpC-315浆细胞瘤的细胞毒性T淋巴细胞反应的体外生成。

Syncytia inhibition by immune lymphocytes: in vitro test for immunity to canine distemper.

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