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首页> 外文期刊>Journal of Clinical Microbiology >Epidemiological usefulness of changes in hemolytic activity of Vibrio cholerae biotype El Tor during the seventh pandemic.
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Epidemiological usefulness of changes in hemolytic activity of Vibrio cholerae biotype El Tor during the seventh pandemic.

机译：第七次大流行期间霍乱弧菌生物型El Tor溶血活性变化的流行病学实用性。

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Hemolytic Vibrio cholerae biotype El Tor strains were isolated in the United States in 1973 and 1978 after they had supposedly disappeared worldwide during the 1960s and 1970s. We decided to examine the change in prevalence of hemolytic El Tor strains since the beginning of the seventh pandemic and evaluate the usefulness of hemolytic activity as an epidemiological marker. A total of 48 isolates of V. cholerae biotype El Tor isolated in the Eastern Hemisphere between 1960 and 1979, along with 1 Texas (1973) and 38 Louisiana (1978) isolates, were tested for hemolytic activity by each of four methods. One method (utilizing heart infusion broth with 1% glycerol) was slightly superior for detecting hemolytic activity. Titers obtained with this method ranged from less than 2 to 1,024. Of 13 (76.9%) strains from the earliest part of the current pandemic, 10 were hemolytic, compared with 1 of 26 (3.8%) strains isolated in the period from 1966 to 1979 in the Eastern Hemisphere, indicating that nonhemolytic El Tor strains have replaced the hemolytic variety there. In contrast, all 38 Louisiana isolates and the Texas isolate were strongly hemolytic. Hemolytic activity was concluded to be a useful epidemiological marker.
机译：溶血霍乱弧菌生物型El Tor菌株于1973年和1978年在美国分离，据说它们已在1960年代和1970年代在世界范围内消失。我们决定研究自第七次大流行开始以来溶血性El Tor菌株的流行率变化，并评估溶血活性作为流行病学标记的有用性。通过四种方法分别测试了1960年至1979年在东半球分离的霍乱弧菌生物型El Tor的48个分离株，以及1个Texas（1973）和38个路易斯安那州（1978）分离株的溶血活性。一种方法（利用含1％甘油的心脏输液肉汤）在检测溶血活性方面略胜一筹。用这种方法得到的滴度范围从小于2到1,024。在当前大流行初期，有13（76.9％）株发生溶血，而从1966年至1979年在东半球分离出的26株（3.8％）中有1株发生溶血，表明非溶血性El Tor株具有取代了那里的溶血品种。相反，路易斯安那州的所有38个分离株和德克萨斯州的分离株均具有强烈的溶血作用。溶血活性被认为是有用的流行病学标记。

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