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首页> 外文期刊>Journal of Clinical Microbiology >Antibody response to human immunodeficiency virus type 1 protease according to risk group and disease stage.
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Antibody response to human immunodeficiency virus type 1 protease according to risk group and disease stage.

机译：根据风险人群和疾病阶段对人免疫缺陷病毒1型蛋白酶的抗体反应。

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Three groups with different routes of human immunodeficiency virus type 1 (HIV-1) transmission (homosexual men, hemophiliacs, and children) were studied for serum antibodies to a recombinant form of the HIV-1 protease using an enzyme-linked immunoassay. At 1 year after seroconversion, defined as the moment antibodies to HIV-1 proteins were first detected, 56% (34/61) of the homosexual men had antibodies to protease, and 2 years after seroconversion this percentage was 63% (24/38). Within this 2-year period these antibodies were no longer detected in 16% (9/56). A similar pattern was observed in 20 hemophiliacs who seroconverted after exposure to HIV-1-contaminated blood products. We found that 63% (160/255) of homosexual men in Centers for Disease Control stage II or III, 60% (9/15) of patients with acquired immunodeficiency syndrome (AIDS)-related complex, and 36% (14/39) of patients with AIDS had antibodies to protease. In 255 homosexual men in Centers for Disease Control stage II or III, antibodies to protease were significantly more frequently found in samples lacking HIV-1 antigen (P less than 0.001) and possessing antibodies to HIV-1 core proteins (P less than 0.001). Twenty-four persons who developed AIDS were studied longitudinally: 58% (14/24) had antibodies to protease 1 year before developing symptoms; 29% (7/24) showed a decline and 29% (7/24) showed a loss of antibodies to protease at the onset of symptoms. Within a group of 47 HIV-1-infected children, 90% (18/20) with a stable disease course were persistently protease antibody positive, versus 4 of 27 children (15%) with an unstable disease course (P = 0.0001). These data indicate that HIV-1 protease is expressed and antigenic in most HIV-1-infected individuals and that a decline or absence of antibodies to protease is strongly associated with unstable disease in children and AIDS in adults.
机译：使用酶联免疫分析法研究了三种具有不同途径的人类1型免疫缺陷病毒（HIV-1）传播途径的组（同性恋男性，血友病和儿童），以检测针对重组形式HIV-1蛋白酶的血清抗体。血清转化后1年（即首次检测到HIV-1蛋白抗体的那一刻），有56％（34/61）的同性恋男性具有蛋白酶抗体，而血清转化后2年，这一百分比为63％（24/38） ）。在这2年内，这些抗体的检出率不再为16％（9/56）。在暴露于受HIV-1污染的血液制品后发生血清转化的20名血友病患者中观察到了类似的模式。我们发现，疾病控制中心II或III期的同性恋男性中有63％（160/255），获得性免疫缺陷综合症（AIDS）相关综合症的患者中有60％（9/15），36％（14/39） ）患有艾滋病的患者的蛋白酶抗体。在疾病控制中心II或III阶段的255名同性恋男性中，蛋白酶抗体在缺乏HIV-1抗原（P小于0.001）且具有HIV-1核心蛋白抗体（P小于0.001）的样本中更常见。 。纵向研究了二十四名患有艾滋病的人：58％（14/24）在出现症状前1年具有蛋白酶抗体。在症状发作时29％（7/24）呈下降趋势，而29％（7/24）显示对蛋白酶的抗体丧失。在一组47名感染HIV-1的儿童中，病程稳定的90％（18/20）持续呈蛋白酶抗体阳性，而病程不稳定的27名儿童中有4名（15％）（P = 0.0001）。这些数据表明，HIV-1蛋白酶在大多数感染HIV-1的个体中表达并具有抗原性，并且蛋白酶抗体的降低或缺失与儿童不稳定疾病和成人AIDS密切相关。

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